The Use of an Uroselective Alpha-1-antagonist to Reduce the Incidence and Duration of Postoperative Urinary Retention Following Spine Surgery
The Use of an Uroselective Alpha-1-antagonist to Reduce the Incidence and Duration of Postoperative Urinary Retention Following Spine Surgery
The purpose of this research is to see if the use of tamsulosin can decrease both the incidence and duration of urinary retention, as well as hospital length of stay following spine surgery.
Postoperative urinary retention is a frequent complication of spinal surgeries and impacts a large portion of this population which results in increased morbidity as a result of increased number of catheterizations, urinary tract infections and prolonged hospital stays. With the addition of Tamsulosin, we would anticipate a reduction in the incidence and duration of postoperative urinary retention and therefore a reduction in morbidity related to treatment of urinary retention as well as shortened hospital stays.
Inclusion Criteria:
Exclusion Criteria:
Cervical Anterior Discectomy and Fusion
Cervical Anterior Corpectomy
Cervical Posterior Discectomy
Cervical Foraminotomy
Lumbar Discectomy (METRx or Open)
Lumbar Foraminotomy
Lumbar Anterior Fusion
Myelopathy with bladder dysfunction
Patients currently taking an alpha-antagonist
o The following drugs are alpha antagonists: alfuzosin, doxazosin, prazosin, terazosin, tamsulosin, and phenoxybenzamine.
Patients with history of allergy or sensitivity to tamsulosin or other alpha-antagonist
History of prostatectomy or urologic surgery involving the bladder or urethra
Severe liver disease or end-stage renal disease
Patients taking strong inhibitors of CYP3A4
o The following drugs are strong inhibitors of CYP3A4: ketoconazole, itraconazole, clarithromycin, ritonavir, indinavir/ritonavir, lopinavir/ritonavir, and conivaptan.
Mental disability or prisoner
Pregnancy (for anesthesia purposes)
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