Pilot testing of EMPOWER, a group sexual health intervention, to increase uptake and persistence of PrEP

This study will pilot test the telehealth intervention EMPOWER (Enhancing and Motivating PrEP Options among Women through Empowerment and Resilience) by adapting an evidence-informed intervention, POWER (Progressing Our Well-Being, Emotions, and Relationships) based on mindfulness and cognitive behavioral therapy, to improve PrEP uptake and persistence by Black women in the South.

Conduct a waitlist-controlled, randomized pilot trial of the 6-session group intervention using a crossover design with 80 Black women. Clinical outcomes will be the PrEP uptake and PrEP persistence measured by TDF via the dried blood spot at baseline, 3- and 6-months post-intervention. We will also assess the intervention's feasibility, acceptability, and usability. The outcomes will be compared with the usual standard of care (opt-out PrEP) at the intervention site.

Inclusion Criteria:

1. Identification as cis-gendered Black woman;
2. Age 18 and older;
3. Engaging in risky sexual behavior in prior 3 months (condomless vaginal or anal sex with a non-main partner, or a partner with known or suspected risk behavior such as injection drug use or HIV/STI, multiple sex partners, transactional sex);
4. Access to a device with a screen, a web browser, and adequate internet speed (e.g., smartphone, computer) for videoconferencing;
5. Able to speak and read English; and
6. No plans to leave the Atlanta, GA area during the duration of study participation.

Exclusion Criteria:

1. Cognitive or mental health condition that limits the ability to provide informed consent;
2. Self-reported use of PrEP or PEP medication in the past three months;
3. Unable to speak and read English; and
4. Currently living with HIV.

Cisgender women

Investigators will not share the IPD of the participants of this study with others because the investigaotrs will only report the aggregated results of the study.