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The efficacy of B-hydroxy-β-methybutyrate in sarcopenia
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control | No Intervention | EEN | |
| Experiment | Experimental | EEN+HMB |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| HMB | Dietary Supplement | EEN+HMB |
|
| Measure | Description | Time Frame |
|---|---|---|
| muscle strength improvement | Grip strength was measured using an electronic dynamometer. Participants sat in an armchair with the upper arm in the adducted neutral position, the elbow flexed at 90°, and the forearm and wrist relaxed naturally. The test hand held the dynamometer and was instructed to squeeze with maximal force smoothly until reaching the peak value, without any twisting or jerking movements of the forearm or hand. After completing the measurement, the other hand was tested using the same method. Each trial was performed three times per hand with a one-minute interval between trials. The maximum value among the six trials was recorded as the final result. | Week 4; Week 8 |
| Measure | Description | Time Frame |
|---|---|---|
| Improvement of muscle mass | Appendicular skeletal muscle mass (ASM) was assessed in this study using a body composition analyzer. ASM was defined as the sum of muscle mass in the arms and legs. During the measurement, patients were required to fast, empty their bowels and bladder, wear light clothing, and undergo the test before exercise, bathing, or showering. Female patients were instructed to avoid measurements during menstruation. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Kang Chao | The Sixth Affiliated Hospital, Sun Yat-sen University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Sixth Hospital Affiliated to Sun Yat-sen University | Guangzhou | Guangdong | 570000 | China |
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| Week 4; Week 8 |
| Clinical response | A decrease in the Crohn's Disease Activity Index (CDAI) by ≥70 points or a CDAI <150. | Week 4; Week 8 |
| Clinical remission | CDAI <150. | Week 4; Week 8 |
| Mucosal healing | No visible ulcers on endoscopy. | Week 4; Week 8 |
| Clinical relapse | CDAI ≥250 at any visit, or CDAI between 150-250 at two consecutive visits one week apart, with an increase of at least 70 points, accompanied by either CRP >5 mg/L or fecal calprotectin >250 μg/g. | Week 4; Week 8 |