Simple Surgical Glove Compression to Prevent Chemotherapy-Induced Peripheral Neuropathy

An Exploratory Self-Controlled Study on the Preventive Effect of the Simple Surgical Glove Compression Technique Against Chemotherapy-Induced Peripheral Neuropathy

To evaluate the preventive efficacy of a simple surgical glove compression technique in reducing the incidence and severity of Chemotherapy Induced Peripheral Neuropathy among patients receiving chemotherapy.

Inclusion Criteria:

• Age ≥ 18 years;
• Histologically confirmed primary invasive breast cancer;
• Planned to receive ≥ 8 weeks of weekly neoadjuvant chemotherapy (utidelone plus cisplatin);
• ECOG performance status: 0-1;

Exclusion Criteria:

• Distant metastasis;
• Presence of sensory or motor neurological disorders, or symptoms related to peripheral neuropathy with CTCAE grade ≥ 2, or currently receiving medication for peripheral neuropathy;
• Conditions affecting limb function;
• Known allergy to glove materials (e.g., latex)