India HIV-CervCa Project

Comparison of Treatment Adherence and Toxicities of HIV Positive Patients Versus HIV Negative Cervical Cancer Patients in India

The investigators propose to prospectively study the difference in treatment (CTRT) completion and toxicities between HIV positive and HIV negative women in India with locally advanced cervical cancer receiving CTRT.

This study will compare chemoradiation completion rates for cervical cancer in two groups, women with HIV and women without HIV. The investigators will also be analyzing tumor tissue for tumor infiltrating lymphocytes which are thought to be involved in disease progression.

Inclusion Criteria:

• patients with newly biopsy proven squamous carcinoma or adenocarcinoma of the uterine cervix, FIGO stage IB2-IIIB in whom curative CTRT is planned
• Karnofsky performance status ≥ 70
• Patients with lower paraortic lymph nodes (below the level of L2 vertebra)
• patients diagnosed with cervical cancer whom also HIV positive or HIV negative

Exclusion Criteria:

• patients with active tuberculosis