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This study will use routinely collected perioperative data to examine the relationship between intraoperative perfusion index and postoperative outcomes, including mortality.
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| Measure | Description | Time Frame |
|---|---|---|
| All-cause mortality | 30 days from time of surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Composite Adverse Outcome | Proportion of participants who experience ≥1 of the following within 30 days after index surgery:
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Inclusion Criteria:
Exclusion Criteria:
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We include every adult patient who underwent general anesthesia for non-cardiac surgery of any type in Danish hospitals in The Capital and Zealand Regions from January 2017 - December 2024.
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| Name | Affiliation | Role |
|---|---|---|
| Nicolai B Foss, Prof | Copenhagen University Hospital, Hvidovre | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Copenhagen University Hospital - Hvidovre | Hvidovre | 2650 | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38242802 | Background | Krone S, Bokoch MP, Kothari R, Fong N, Tallarico RT, Sturgess-DaPrato J, Pirracchio R, Zarbock A, Legrand M. Association between peripheral perfusion index and postoperative acute kidney injury in major noncardiac surgery patients receiving continuous vasopressors: a post hoc exploratory analysis of the VEGA-1 trial. Br J Anaesth. 2024 Apr;132(4):685-694. doi: 10.1016/j.bja.2023.11.054. Epub 2024 Jan 19. | |
| 34226038 |
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Data cannot be made available due to ethical and regulatory restrictions.
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| SAP | No | Yes | No | Statistical Analysis Plan | Aug 24, 2025 | Sep 2, 2025 | SAP_000.pdf |
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| 30 days from time of surgery |
| Postoperative ICU Admission | Any ICU admission occurring after index surgery and within 30 days. | 30 days from date of surgery |
| Reoperation | Any return to the operating room within 30 days of index surgery. | 30 days from date of surgery |
| Prolonged Length of Stay (LOS) | Proportion of participants whose index-hospitalization LOS (days from surgery to discharge) falls in the 75th-100th percentile for their surgical category, determined from the study cohort distribution and assessed at discharge. | Through hospital discharge (max. 6 months from surgery date) |
| Acute Kidney Injury | AKI defined by KDIGO criteria (≥1.5× baseline serum creatinine within 7 days or ≥0.3 mg/dL increase within 48 h) occurring within 30 days of surgery. | 30 days from date of surgery |
| Background |
| Agerskov M, Thusholdt ANW, Holm-Sorensen H, Wiberg S, Meyhoff CS, Hojlund J, Secher NH, Foss NB. Association of the intraoperative peripheral perfusion index with postoperative morbidity and mortality in acute surgical patients: a retrospective observational multicentre cohort study. Br J Anaesth. 2021 Sep;127(3):396-404. doi: 10.1016/j.bja.2021.06.004. Epub 2021 Jul 3. |