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This study investigated how anterior cruciate ligament (ACL) injuries affect not only the knee joint but also brain activity, reaction speed, and psychological readiness to return to sports. A total of 60 male athletes, aged 18 to 30 years, were evaluated in three groups: healthy athletes, athletes who had undergone primary ACL reconstruction, and athletes who had undergone revision ACL reconstruction.
The study measured brain activity with electroencephalography (EEG), reaction time with a computer-based test, and psychological status with standardized questionnaires. The findings showed that athletes with revision ACL surgery had more difficulties in attention control, slower reaction times, and greater psychological barriers compared to the other groups.
These results suggest that ACL injuries and surgeries may influence not only physical recovery but also brain function and psychological readiness. The study highlights the importance of considering neuromuscular, cognitive, and emotional aspects when planning rehabilitation and return-to-sport decisions.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Healthy Control Group | Athletes with no history of knee injury or surgery (n=20). | ||
| Primary ACL Reconstruction Group | Athletes who had undergone a single ACL reconstruction, with rehabilitation completed at least 6 months prior to enrollment (n=20). | ||
| Revision ACL Reconstruction Group | Athletes who had undergone at least two ACL surgeries including revision, with rehabilitation completed at least 6 months prior to enrollment (n=20). |
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| Measure | Description | Time Frame |
|---|---|---|
| Frontal EEG Theta/Beta Ratio | Cortical activity measured at F3 and F4 electrode sites using EEG (Nexus-10 system, Mind Media, Netherlands). Theta (4-8 Hz) and beta (13-21 Hz) power spectral densities were calculated and the ratio (theta/beta) was used as an indicator of attentional control. Higher ratios indicate reduced attention and cognitive efficiency. | Single assessment on the study day (June-July 2025) |
| Measure | Description | Time Frame |
|---|---|---|
| Visual Reaction Time (ms) | Computer-based visual response task; mean reaction time (ms) computed across 5 valid trials after practice. Longer times indicate lower sensorimotor efficiency. | Single assessment on the study day (June-July 2025) |
| Kinesiophobia (TSK-11 total score) |
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Inclusion Criteria:
Male athletes
Age between 18 and 30 years
Regular participation in amateur or professional sports
Completion of ACL rehabilitation (for surgical groups) at least 6 months before enrollment
Ability to undergo EEG and reaction time testing
Provision of signed informed consent
Exclusion Criteria:
History of neurological or psychiatric conditions (e.g., epilepsy, ADHD, depression)
Additional lower extremity injuries or orthopedic surgeries
Metal implants or scalp conditions incompatible with EEG
Uncorrected visual or auditory deficits
Systemic illnesses (e.g., diabetes, multiple sclerosis, neuropathy)
Use of psychoactive medication
Any cognitive or physical limitation interfering with testing procedures
Female participants (to avoid hormonal confounding effects on EEG recordings)
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The study population consisted of 60 male athletes aged 18 to 30 years. Participants were divided into three groups: healthy controls with no history of knee injury, athletes with primary ACL reconstruction, and athletes with revision ACL reconstruction. All were actively engaged in regular sports participation and had completed ACL rehabilitation at least 6 months prior to enrollment.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Duzce University | Düzce | 81620 | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41318585 | Derived | Kaya HB, Karaduman ZO, Akpinar S, Arican M, Saglam S, Aksit S, Koc M, Uludag V. Neuromusculoskeletal alterations after ACL reconstruction: a cross-sectional study of cortical activity, motor response, and psychological readiness. BMC Sports Sci Med Rehabil. 2025 Nov 29;18(1):65. doi: 10.1186/s13102-025-01450-6. |
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Individual participant data (IPD) will not be shared because the dataset is small, contains sensitive neurophysiological and psychological information, and was collected under conditions that limit external data access. Data may be available in aggregated form upon reasonable request to the corresponding author.
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| ID | Term |
|---|---|
| D000070598 | Anterior Cruciate Ligament Injuries |
| D001265 | Athletic Injuries |
| D000092442 | Kinesiophobia |
| ID | Term |
|---|---|
| D007718 | Knee Injuries |
| D007869 | Leg Injuries |
| D014947 | Wounds and Injuries |
| D010698 | Phobic Disorders |
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Tampa Scale of Kinesiophobia-11; 11 items, 1-4 Likert; total score 11-44. Higher scores indicate greater fear of movement/reinjury. |
| Single assessment on the study day (June-July 2025) |
| Psychological Readiness to Return to Sport (ACL-RSI total score) | ACL-RSI questionnaire; 12 items scored 0-100; total reported as mean (0-100). Higher scores indicate greater psychological readiness. | Single assessment on the study day (June-July 2025) |
| D001008 |
| Anxiety Disorders |
| D001523 | Mental Disorders |