This is a prospective cohort study, patients with coralloid nephrolithiasis. Purpose of the study: to evaluate the efficacy and safety of litholytic therapy of coral-like urate nephrolithiasis with citrate mixtures.

Anthropometric parameters height and weight were recorded in all patients, body mass index was calculated. All patients underwent MSCT of the urinary tract to assess the volume of density and concrements before the start of therapy. Biochemical blood analysis included determination of creatinine level with subsequent calculation of SCF. Urine pH was monitored for 72 hours using an electronic pH meter before therapy and recorded in a diary by patients three times a day, after which the average pH was calculated. Patients who met the inclusion criteria were included in the study after signing informed consent.

• Coral-shaped calculus, which fills one or more calyx and pelvis (K2-K4 according to the classification of coral-shaped concretions);
• The urate composition of the kidney stone was confirmed using dual-energy MSCT;
• Unimpaired or restored (by draining the kidney) urine outflow from the kidney;
• Persistently acidic urine pH (pH 5.8 or less);
• Stone density is 550 Hounsfield units or less;
• Informed voluntary consent of the patient to participate in the study;
• Patient's readiness for conservative treatment;
• No contraindications to therapy with citrate mixtures;