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Use of QRX-3 in hospitalized patients with pediatric and adult patients with acute tubular necrosis renal failure
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Use of QRX-3 in addition to standard therapy | Experimental | QRX-3 drug orally as twice daily in addition to standard conventional therapy will be given to this group for 28 days |
|
| control group | Placebo Comparator | placebo twice daily will be given to this group in addition to standard therapy |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| QRX-3 | Drug | Combination of QRX-3 with standard therapy will be given to one arm in trial , another arm will receive placebo |
|
| Measure | Description | Time Frame |
|---|---|---|
| Rate of change in creatinine glomerular filtration rate | compare the outcome effect of added QRX-3 drug to placebo in addition to standard therapy on the rate of change from baseline of creatinine GFR in ATN patients | 28 days |
| Measure | Description | Time Frame |
|---|---|---|
| daily change in glomerular filtration rate in ml/min | daily change in GFR by creatinine in mls/min | 7 days |
| daily change in cystatin C level in mg/dl | daily change in measured cystatin C level |
| Measure | Description | Time Frame |
|---|---|---|
| effect of QRX-3 on recovery of renal function in patients with ATN renal failure | comparism of number of patient achieving return to baseline renal function in both groups | 28 |
Inclusion Criteria:
Exclusion Criteria:
High risk of bleeding Absence of hydronephrosis or obstructive uropathy Absence of baseline dialysis use single kidney status
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ebima Okundaye, MD | Contact | 9738855457 | cliffordebima@gmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Neukidney Inc | Rosharon | Texas | 77583 | United States |
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| ID | Term |
|---|---|
| D058186 | Acute Kidney Injury |
| D007673 | Kidney Cortex Necrosis |
| ID | Term |
|---|---|
| D051437 | Renal Insufficiency |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
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added QRX-3 to standard regime
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|
| 7 days |
| D005261 |
| Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |