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The goal of this observational study is to evaluate Metabolic Health by fit analysis between calculated Nutrilite Metabolic Health Index and the result of Metabolomics analysis from blood plasma samples in healthy adult participants aged between 18 and 60 years. The main question it aims to answer:
- Does the Nutrilite Metabolic Health Index fit well with the result of Metabolomics analysis from blood plasma samples?
200 eligible participants will be enrolled in a single center, one site visit will be made to finish a health questionnaire, a lifestyle questionnaire, a routine physical checkup. Blood samples will be collected for routine blood test (blood sugar, total triglycerides, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, uric acid), and for Metabolomics testing.
Researchers will calculate the Nutrilite Metabolic Health Index based on participant data, and do the fit analysis against the result from Metabolomics analysis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| All participants | All participants enrolled will be asked to fill out the questionnaires, have physical checkup, and take blood samples, no interventions involved. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| No Intervention: Observational Cohort | Other | No intervention involved, participants will fill out some questionnaires and blood samples will drawn for test and analysis. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Nutrilite Metabolic Health Index | Nutrilite Metabolic Health Index incorporates seven core biochemical parameters (see details in Secondary Outcome Measures): body mass index (BMI), waist circumference, fasting blood glucose (FBG) level, blood lipid profile (total cholesterol (TC), total triglycerides(TG), Low-Density Lipoprotein Cholesterol (LDL), High-Density Lipoprotein Cholesterol (HDL), blood pressure (Systolic Blood Pressure(SBP), and Diastolic Blood Pressure (BDP)), uric acid level, and history of fatty liver disease; along with four lifestyle and hereditary factors: smoking, alcohol consumption, age, and family history of metabolic diseases. After weighted calculation, the index score ranges from 0 to 100, divided into four grades: Excellent: 85-100 Moderate: 60-84 Poor: 40-59 Severe: 0-39 | day 1 |
| Measure | Description | Time Frame |
|---|---|---|
| SBP | SBP(Systolic Blood Pressure), ideally <120 mmHg or still normal if less than 130mmHg | day 1 |
| DBP | BDP(Diastolic Blood Pressure), ideally <80 mmHg, or still normal if less than 89 mmHg |
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Inclusion Criteria:
Exclusion Criteria:
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Male and female participants, aged 18 to 60, regardless of gender;
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Charlie Zhang, MD | Contact | +8613901981272 | charlie.zhang@raisonbiotech.com |
| Name | Affiliation | Role |
|---|---|---|
| Zheng Qu | Shanghai MCC Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Shanghai MCC Hospital | Shanghai | Shanghai Municipality | 201900 | China |
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| ID | Term |
|---|---|
| D008659 | Metabolic Diseases |
| ID | Term |
|---|---|
| D009750 | Nutritional and Metabolic Diseases |
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| day 1 |
| Blood test - LDL-C | LDL-C(Low-Density Lipoprotein Cholesterol) concentration level in the blood sample test: normal range 0-3.1mmol/L, higher than 3.1 mmol/L is abnormal; | day 1 |
| Blood test - HDL-C | HDL-C(High-Density Lipoprotein Cholesterol) concentration level in the blood sample test: normal range 1.04~1.55 mmol/L, lower than 1.04 or higher than 1.55 mmol/L is abnormal; | day 1 |
| Blood test - TG | TG (Triglyceride) concentration level in the blood sample test : normal range 0~1.7 mmol/L, higher than 1.7mmol/L is abnormal | day 1 |
| Blood test - TC | TC (Total Cholesterol) concentration level in the blood sample test: normal range 3-5.2 mmol/L; higher than 5.2 mmol/L is abnormal. | day 1 |
| Blood test - FBG | FBG(Fasting Blood Glucose) concentration level in the blood sample test: normal range 4.-5.5mmol/L, higher than 5.5 mmol/L is abnormal. | day 1 |
| BMI | BMI (Body Mass Index), BMI is calculated by weight/height^2, where weight measured with unit kg, and height with unit meter, and weight and height will be combined to report BMI in kg/m^2. | day 1 |
| Waist Circumference | waist circumference measured in cm (centimeter) | day 1 |
| Uric Acid Level | uric acid level in μmol/L, the normal range for adult male:149~416μmol/L, adult female:89~357μmol/L | day 1 |