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Patient with atraumatic knee pain without a large knee effusion on x-ray will be randomized to receive either a genicular nerve block (GNB) or standard of care in the emergency department.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Genicular Nerve Block | Experimental | This arm of patients (17 total) will receive the genicular nerve block for their knee pain. |
|
| Standard of Care | Active Comparator | This arm of patients (17 total) will receive standard of care analgesia for their knee pain |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Genicular nerve block with bupivacaine and corticosteroids | Procedure | genicular nerve block with ideal body-weight dosing of bupivacaine 0.5% with 4 mg dexamethasone |
|
| Measure | Description | Time Frame |
|---|---|---|
| Pain level | Measured by numeric rating scale: 0 (minimum value) - 10 (maximum value) | 1 hour post-enrollment |
| Measure | Description | Time Frame |
|---|---|---|
| Difference in Duration of Analgesia | Patients will be called back to assess their pain levels | 24 hours |
| Difference in AP-POQ-RED score | 9 question survey study, all questions rated on 0 (minimum) - 10 (maximum) scale. Questions include: pain before and after treatment, pain with activities in and out of bed, emotions (anxiety, fear, helplessness), degree of pain relief in the emergency department, satisfaction. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Umar Clinical Research Coordinator, AB | Contact | 267-624-4394 | umar.aulia@pennmedicine.upenn.edu |
| Name | Affiliation | Role |
|---|---|---|
| Michael M Shalaby, MD | University of Pennsylvania | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hospital of the University of Pennsylvania | Recruiting | Philadelphia | Pennsylvania | 19104 | United States |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot | Yes | No | No | Study Protocol | May 16, 2025 | Jul 16, 2025 | Prot_000.pdf |
| ICF | No | No | Yes | Informed Consent Form | May 16, 2025 | Jul 28, 2025 | ICF_001.pdf |
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| ID | Term |
|---|---|
| D002045 | Bupivacaine |
| D000305 | Adrenal Cortex Hormones |
| D059039 | Standard of Care |
| ID | Term |
|---|---|
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 | Aniline Compounds |
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| Standard of Care | Other | This involves standard of care pain relief for patients who do not receive the genicular nerve block for knee pain, such as acetaminophen, non-steroidal anti-inflammatory drugs (NSAIDs), and opioids. |
|
| 1 hour after enrollment |
| Difference in length of stay in the emergency department | Length of stay in the emergency department is determined from the time the provider first sees the patient to the time the provider discharges the patient. | Average 1 hour |
| Pennsylvania Hospital | Recruiting | Philadelphia | Pennsylvania | 19104 | United States |
|
| Pennsylvania Presbyterian Medical Center | Recruiting | Philadelphia | Pennsylvania | 19104 | United States |
|
| HUP Cedar | Recruiting | Philadelphia | Pennsylvania | 19143 | United States |
|
| D000588 |
| Amines |
| D006728 | Hormones |
| D006730 | Hormones, Hormone Substitutes, and Hormone Antagonists |
| D019984 | Quality Indicators, Health Care |
| D011787 | Quality of Health Care |
| D006298 | Health Services Administration |
| D017530 | Health Care Quality, Access, and Evaluation |