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| ID | Type | Description | Link |
|---|---|---|---|
| 19TPA34890033 | Other Grant/Funding Number | American Heart Association |
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This is a clinical trial to determine if 30 sessions of far infrared sauna bathing can improve cardiovascular and metabolic function in adults with obesity.
Obesity can increase the risk for cardiovascular and metabolic diseases. Lifestyle interventions are needed to reduce this risk. Far infrared saunas are one form of heat therapy that may help reduce these risks, however, there is limited research within a population with obesity. It is hypothesized that repeated far infrared sauna bathing will improve cardiovascular and metabolic function in adults with obesity.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Heat therapy | Experimental | Group will undergo 30 sessions of heat therapy over approximately 10 weeks. Sessions will require participants to sit in a far infrared sauna for up to 45 min for 3 to 4 times per week. |
|
| Time control group | No Intervention | No participation in sauna bathing. Maintain lifestyle habits for approximately 10 weeks. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Heat therapy | Other | 30 sessions of far infrared sauna bathing (45-60C) for up to 45 min |
|
| Measure | Description | Time Frame |
|---|---|---|
| Blood pressure change | Change in systolic and diastolic blood pressures after 30 sessions of Intervention | 10 weeks |
| Blood glucose | Change in plasma glucose levels after Intervention | 10 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Arterial stiffness reduction | Change in Carotid-femoral Pulse Wave Velocity (m/s) after Intervention | 10 weeks |
| Serum insulin | Change in serum insulin levels after Intervention |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Christopher T Minson, PhD | Contact | 541-346-7583 | minson@uoregon.edu | |
| John R Halliwill, PhD | Contact | 541-346-7591 | halliwil@uoregon.edu |
| Name | Affiliation | Role |
|---|---|---|
| Christopher T Minson, PhD | University of Oregon | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Oregon | Recruiting | Eugene | Oregon | 97401 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 16088266 | Background | Masuda A, Koga Y, Hattanmaru M, Minagoe S, Tei C. The effects of repeated thermal therapy for patients with chronic pain. Psychother Psychosom. 2005;74(5):288-94. doi: 10.1159/000086319. | |
| 11869837 | Background | Kihara T, Biro S, Imamura M, Yoshifuku S, Takasaki K, Ikeda Y, Otuji Y, Minagoe S, Toyama Y, Tei C. Repeated sauna treatment improves vascular endothelial and cardiac function in patients with chronic heart failure. J Am Coll Cardiol. 2002 Mar 6;39(5):754-9. doi: 10.1016/s0735-1097(01)01824-1. |
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| ID | Term |
|---|---|
| D009765 | Obesity |
| D000084462 | Hyperthermia |
| D007333 | Insulin Resistance |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| D003972 | Diathermy |
| ID | Term |
|---|---|
| D006979 | Hyperthermia, Induced |
| D013812 | Therapeutics |
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Time control versus heat therapy group
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| 10 weeks |
| 15564698 | Background | Kihara T, Biro S, Ikeda Y, Fukudome T, Shinsato T, Masuda A, Miyata M, Hamasaki S, Otsuji Y, Minagoe S, Akiba S, Tei C. Effects of repeated sauna treatment on ventricular arrhythmias in patients with chronic heart failure. Circ J. 2004 Dec;68(12):1146-51. doi: 10.1253/circj.68.1146. |
| 39373667 | Background | Fuchs CJ, Betz MW, Petrick HL, Weber J, Senden JM, Hendriks FK, Bels JLM, van Loon LJC, Snijders T. Repeated passive heat treatment increases muscle tissue capillarization, but does not affect postprandial muscle protein synthesis rates in healthy older adults. J Physiol. 2025 Jan;603(1):167-186. doi: 10.1113/JP286986. Epub 2024 Oct 7. |
| 31483156 | Background | Ely BR, Francisco MA, Halliwill JR, Bryan SD, Comrada LN, Larson EA, Brunt VE, Minson CT. Heat therapy reduces sympathetic activity and improves cardiovascular risk profile in women who are obese with polycystic ovary syndrome. Am J Physiol Regul Integr Comp Physiol. 2019 Nov 1;317(5):R630-R640. doi: 10.1152/ajpregu.00078.2019. Epub 2019 Sep 4. |
| 31136202 | Background | Ely BR, Clayton ZS, McCurdy CE, Pfeiffer J, Needham KW, Comrada LN, Minson CT. Heat therapy improves glucose tolerance and adipose tissue insulin signaling in polycystic ovary syndrome. Am J Physiol Endocrinol Metab. 2019 Jul 1;317(1):E172-E182. doi: 10.1152/ajpendo.00549.2018. Epub 2019 May 28. |
| 27707723 | Background | Brunt VE, Jeckell AT, Ely BR, Howard MJ, Thijssen DH, Minson CT. Acute hot water immersion is protective against impaired vascular function following forearm ischemia-reperfusion in young healthy humans. Am J Physiol Regul Integr Comp Physiol. 2016 Dec 1;311(6):R1060-R1067. doi: 10.1152/ajpregu.00301.2016. Epub 2016 Oct 5. |
| 27418688 | Background | Brunt VE, Eymann TM, Francisco MA, Howard MJ, Minson CT. Passive heat therapy improves cutaneous microvascular function in sedentary humans via improved nitric oxide-dependent dilation. J Appl Physiol (1985). 2016 Sep 1;121(3):716-23. doi: 10.1152/japplphysiol.00424.2016. Epub 2016 Jul 14. |
| 35323077 | Background | Behzadi P, Ravanelli N, Gravel H, Barry H, Debray A, Chaseling GK, Jacquemet V, Neagoe PE, Nigam A, Carpentier AC, Sirois MG, Gagnon D. Acute effect of passive heat exposure on markers of cardiometabolic function in adults with type 2 diabetes mellitus. J Appl Physiol (1985). 2022 May 1;132(5):1154-1166. doi: 10.1152/japplphysiol.00800.2021. Epub 2022 Mar 24. |
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001832 | Body Temperature Changes |
| D018882 | Heat Stress Disorders |
| D014947 | Wounds and Injuries |
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |