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| ID | Type | Description | Link |
|---|---|---|---|
| TF.ALT.23.10 | Other Grant/Funding Number | GAZÄ°ANTEP ÃœNÄ°VERSÄ°TESÄ° - BÄ°LÄ°MSEL ARAÅžTIRMA PROJELERÄ° KOORDÄ°NASYON BÄ°RÄ°MÄ° |
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| Name | Class |
|---|---|
| University of Gaziantep | OTHER |
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The aim of this study is to compare the efficacy and safety of Thulium Fiber Laser (TFL) litothripsy according to stone density and the factors affecting success in patients undergoing retrograde intrarenal surgery (RIRS) for renal calculi >1000 mm3. Between November 2023 and December 2024, 81 patients with a stone volume >1000 mm3 who underwent RIRS with TFL in our clinic were prospectively and sequentially evaluated. Stone density of the patients was measured, and expressed in Hounsfield Units (HU). Patients with stone densities <1000 HU and ≥1000 HU were categorized as Groups 1, and 2, respectively. Demographic data, data of intraoperative laser use, stone-free rates (SFRs), the need for a second session of RIRS and complications were recorded. Duration of TFL litothripsy, total energy used, laser ablation speed (mm3/sec), laser ablation efficiency (mm3/J) and laser energy consumption (J/mm3) were calculated. Correlation tests, univariate and multivariate logistic regression tests were used for statistical analysis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Safety and Efficacy of Thulium Fiber Laser for Large Renal Stones | Experimental | Demographic data (age, gender, body mass index (BMI)), stone characteristics (size, location, Hounsfield Unit (HU) value) and durations of the procedures were recorded. Patients over 18 years of age, with kidney stones larger than 1000 mm³, single or multiple stones and those eligible for RIRS were included in the study. Patients under 18 years of age, those with bleeding diathesis or inability to discontinue anticoagulant/antiaggregant therapy, cases with a history of previous RIRS, individuals who did not attend follow-up visits, patients in whom postoperative residual stone assessment could not be made, or had concomitant bladder or ureteral stones were excluded. SFRs, the need for a second session of RIRS and complications were noted. General anesthesia was used. Rigid ureteroscope was inserted through urethral meatus. 11/13 F ureteral sheath was advanced over guidewire under fluoroscopy. Laser settings varied 0.2J/100Hz to 1J/10Hz based on stone fragility. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Effectivity of TFL on large renal stone | Device | While literature studies on TFL have focused on the effect of stone size on laser efficacy parameters, the present study is important as it is a prospective study examining the effects of TFL lithotripsy on SFRs in stones >1000 mm3. |
| Measure | Description | Time Frame |
|---|---|---|
| The primary outcome was to assess the effectiveness of the laser. | Fragmentation success was used to evaluate the laser effectiveness of laser. | 12 months |
| Measure | Description | Time Frame |
|---|---|---|
| The secondary outcome was the evaluation of factors affecting stone-free rates | A residual fragment of ≤2 mm was considered stone-free. The unit of measure for all parameters was the percentage of patients stone-free. | 3 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Gaziantep | Gaziantep | Şehitkamil | 27310 | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41923045 | Derived | Baturu M, Seckiner I, Bayrak O, Kirac M, Ozturk M, Erturhan S. Efficacy of thulium fiber laser litothripsy on large renal stones (> 1000 mm(3)) according to Hounsfield units: a prospective single-center study. BMC Urol. 2026 Apr 1;26(1):122. doi: 10.1186/s12894-026-02138-w. |
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|
| ID | Term |
|---|---|
| D053040 | Nephrolithiasis |
| D007669 | Kidney Calculi |
| ID | Term |
|---|---|
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052878 | Urolithiasis |
| D052801 | Male Urogenital Diseases |
| D014545 | Urinary Calculi |
| D002137 | Calculi |
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |
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