This study aims to evaluate the efficacy of rectal ozone therapy as a neuroprotective modality in Pediatric acquired brain injury.

Acquired brain injury (ABI) from primary neurologic diagnoses accounts for 20% of all pediatric critical care admissions and more than 60,000 hospital admissions annually.

Ozone (O3) gas was discovered in the 1840s, and soon after that, the scientific community began to expand past the notion that it was just another gas of the Earth's atmosphere.

Inclusion Criteria:

• Age from 1 month to 18 years.
• Both sexes.
• Children admitted to the pediatric intensive care unit (PICU) with acquired neurological insult.
• Children with neurological sequelae
• Children who are exposed to acquired brain injury, e.g., traumatic brain injury, cardiac arrest, intracranial hemorrhage, central nervous system infections, stroke, tumor, or hypoxia, with neurological sequelae diagnosed by neurological examination and magnetic resonance imaging (MRI), to detect that disorder early.

Exclusion Criteria:

• Patients with no degree of disability or sequelae.
• Patients not fit for Rectal ozone therapy.
• Patients with active epilepsy and recurrent seizures.
• Children with a positive family history of degenerative brain insults.
• Children with behavioral problems.

The data will be available upon a reasonable request from the corresponding author after the end of study for one year.

After the end of study for one year.

The data will be available upon a reasonable request from the corresponding author.