Effects of Different Antibiotic Regimens in Preterm Premature Rupture of Membranes

Randomized Controlled Trial on the Effects of Different Antibiotic Regimens in Preterm Premature Rupture of Membranes After 34 Weeks

To investigate the effects of different antibiotic regimens used in preterm premature rupture of membranes (PPROM) on maternal and fetal outcomes after 34 weeks of gestation.

Background: To investigate the effects of different antibiotic regimens used in preterm premature rupture of membranes (PPROM) on maternal and fetal outcomes after 34 weeks of gestation.

Methods: A total of 40 pregnant women diagnosed with PPROM after the 34th week of gestation were included in the study and randomly divided into two equal groups. Group-1: Sulbactam + ampicillin, azithromycin, and amoxicillin. Group-2: Ceftriaxone, clarithromycin, and amoxicillin. For all cases, obstetric history, time of delivery, latency period, infection markers, neonatal birth weight, APGAR scores, NICU requirement and length of stay, type of delivery and maternal complications were recorded.

Inclusion Criteria:

• Singleton pregnancies,
• PPROM after 34 weeks of gestation

Exclusion Criteria:

• Patients with fetal anomalies
• Preeclampsia, gestational or pregestational diabetes mellitus,
• Multiple pregnancies,
• Chorioamnionitis, placental abruption, cord prolapse, fetal distress, or other complicated pregnancies.
• Maternal immunodeficiency
• The presence of other infections requiring antibiotic therapy, antenatal corticosteroid use, chronic diseases,
• Unwillingness to participate and sign the detailed informed consent form