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This is an observational, monocentric, retrospective cohort study. Its primary objective is to examine maternal and foetal outcomes in pregnancies that occurred before the diagnosis of systemic lupus erythematosus (SLE) in a group of female participants who were subsequently diagnosed with the condition.
The investigators aim to study obstetrical and systemic signs in participants' pregnancies prior to an SLE diagnosis. Information will be collected from medical records and by asking participants questions during medical visits. The diagnosis of SLE is made using the ACR 1997 criteria. It is also based on renal histological findings.
The study must answer three questions:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Femelle patients at procreation age with diagnosis of LES | Patients that have had pregnancies history before the diagnosis of LES |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Collect data on all pregnancies before and after diagnosis of SLE. | Other | For participants who are still alive, data are collected from interviews with patients using a prepared questionnaire that asks about all pregnancies and obstetrical events prior to the diagnosis of SLE. For deceased patients, data are taken from the medical records of obstetrical events. Data will be collected on anthropometric, biological, immunological, and histological features before and after the diagnosis of SLE, if available. The activity and severity of the disease after diagnosis will be assessed using the recommended tools. |
| Measure | Description | Time Frame |
|---|---|---|
| 1. Primary outcome: Prevalence of obstetrical events before the diagnosis of SLE. Secondary outcome: 1. Assess the severity of the disease at the time of LES diagnosis. 2. Compare the outcomes of pregnancies before and after the LES |
| The patient will be assessed from the beginning of each pregnancy and in the three month after childbirth |
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Inclusion criteria:
Exclusion criteria:
LES was previously diagnosed prior to any conception.
Only biological femelle sex and cis-gender people that have experienced pregnancy are eligible to participate to the study
Eligible patients for the study are selected from all women diagnosed with lupus erythematosus in the Department of Internal Medicine at the Ain-Taya Teaching Hospital from 2000 to 2025. Patients are recruited from primary care, emergency units, or the gynecology and obstetrics department. These patients are being followed up in the Department of Internal Medicine at Ain-Taya Hospital.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Wafia- Nadia Nibouche - Hattab, Professor in medicine | Contact | +213-771-810-932 | wani16000@yahoo.fr |
| Name | Affiliation | Role |
|---|---|---|
| Wafia-Nadia Nibouche-Hattab, Professor of medicine | University of Algiers. Faculty of medicine | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of internal medicine, Ain-Taya's teaching Public hospital | Active, not recruiting | Aïn Taya | Algiers Province | 16019 | Algeria |
All collected IPD
One month after the end of the study, presumely in March 2026 until Avril 2026
the reviewers board of journal if manuscript is accepted. they will be able to access all data collected and statistical study.
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| ID | Term |
|---|---|
| D011248 | Pregnancy Complications |
| ID | Term |
|---|---|
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
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| Ain-Taya's Public Hospital | Recruiting | Algiers | 16019 | Algeria |
|