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This research assessed diaphragmatic ultrasound and thoracic fluid content (TFC) as potential early predictive tools for detecting NIV failure in preterm neonates.
Non-invasive ventilatory support (NIV) is considered a gold standard care for preterm infants with respiratory distress syndrome (RDS); however, NIV failure remains a frequent challenge that is often associated with many adverse outcomes
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| CPAP | 30 infants supported by nasal CPAP |
| |
| NIPPV | 30 infants supported by non-invasive positive pressure ventilation |
| |
| NHFOV | 30 infants supported with nasal high-frequency oscillatory ventilation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Diaphragmatic US | Device | Diaphragmatic thickening fraction (DTF) and diaphragmatic excursion (DE) were measured by ultrasound within the first three hours of life and repeated either 24 hours later in successful cases or immediately before intubation in cases who had NIV failure. |
| Measure | Description | Time Frame |
|---|---|---|
| The predictive value | The predictive value of DTF, DE, and TFC for NIV failure in preterm neonates with RDS. | Two years |
| Measure | Description | Time Frame |
|---|---|---|
| Success Rate | Comparing success rates among CPAP, NIPPV, and NHFOV groups, | Two years |
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Inclusion Criteria:
Exclusion Criteria:
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Preterm neonates (28-34 weeks GA) with RDS and requiring NIV
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| Name | Affiliation | Role |
|---|---|---|
| Heba Saied Elmahdy, Professor | Faculty of Medicine, Tanta University, Tanta, Q2x2+cp Tanta 2, Egypt, 31527 | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Faculty of Medicine, Tanta University | Tanta | Tanta, Q2x2+cp Tanta 2, Egypt | 31527 | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41364345 | Derived | Elgendy EM, Elmahdy HS, Nassar MAE, Zidan LK, Eltomey MA, Elsharkawy HM. Diaphragmatic ultrasound and thoracic fluid content for prediction of non-invasive ventilation failure in neonates: a randomized controlled trial. Eur J Pediatr. 2025 Dec 9;185(1):3. doi: 10.1007/s00431-025-06605-8. |
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| EC | Device | TFC was assessed using electrical cardiometry (EC). Measurements were obtained within the first three hours of life and repeated either 24 hours later in successful cases or immediately before intubation in cases who had NIV failure. |
|
| ID | Term |
|---|---|
| C566881 | Respiratory Distress Syndrome In Premature Infants |
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