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VKA in RHD patients with MHV: our current status
Vitamin K Antagonist in Rheumatic heart disease patients with mechanical heart valves: Our Current Status
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| Measure | Description | Time Frame |
|---|---|---|
| Time in therapeutic range (TTR) for warfarin. | TTR status will be calculated using the most recent INR value and patient records to determine whether INR is within the target therapeutic range (2.0-3.5) at the time of data collection. | Baseline |
| 2. Correlation Between TTR and Patient-Specific Factors | Assesses the relationship between INR control and factors such as age, comorbidities, adherence, vitamin K intake, and medication use based on data collected at the single study visit. | Baseline |
| Measure | Description | Time Frame |
|---|---|---|
| 1. Number of Participants With Reported Bleeding Events (Major or Minor) | Presence or absence of self-reported or documented major/minor bleeding events prior to or at the time of data collection. | Baseline |
| Number of Participants With Thromboembolic Events |
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Inclusion Criteria:
Exclusion Criteria:
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Data collection: Data will be collected directly by the researcher and will be reviewed by the supervising team to ensure accuracy and consistency. The data collection process will involve recording INR observation , clinical evaluations Each participant will have their data entered into a secure database for further analysis.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ahmed Hassan Rostom, Master | Contact | +201122713232 | +201064030397 | ahmedrostom112@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Hamdy Shams Mohamed | Principal Investigator | |
| Tarek hameed Nageeb | Principal Investigator |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28834488 | Background | Watkins DA, Johnson CO, Colquhoun SM, Karthikeyan G, Beaton A, Bukhman G, Forouzanfar MH, Longenecker CT, Mayosi BM, Mensah GA, Nascimento BR, Ribeiro ALP, Sable CA, Steer AC, Naghavi M, Mokdad AH, Murray CJL, Vos T, Carapetis JR, Roth GA. Global, Regional, and National Burden of Rheumatic Heart Disease, 1990-2015. N Engl J Med. 2017 Aug 24;377(8):713-722. doi: 10.1056/NEJMoa1603693. | |
| 37327912 |
| Label | URL |
|---|---|
| Related Info | View source |
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| ID | Term |
|---|---|
| D012214 | Rheumatic Heart Disease |
| ID | Term |
|---|---|
| D012213 | Rheumatic Fever |
| D013290 | Streptococcal Infections |
| D016908 | Gram-Positive Bacterial Infections |
| D001424 | Bacterial Infections |
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History of stroke, valve thrombosis, or systemic embolism collected from medical records or patient report during the study visit. |
| Baseline |
| Rate of Patient Adherence to Warfarin Therapy | Adherence assessed via patient self-report and/or pill count at the single study visit. | Baseline |
| Background |
| Beckmann A, Meyer R, Lewandowski J, Markewitz A, Blassfeld D, Boning A. German Heart Surgery Report 2022: The Annual Updated Registry of the German Society for Thoracic and Cardiovascular Surgery. Thorac Cardiovasc Surg. 2023 Aug;71(5):340-355. doi: 10.1055/s-0043-1769597. Epub 2023 Jun 16. |
| 35210036 | Background | El-Hamamsy I, Toyoda N, Itagaki S, Stelzer P, Varghese R, Williams EE, Erogova N, Adams DH. Propensity-Matched Comparison of the Ross Procedure and Prosthetic Aortic Valve Replacement in Adults. J Am Coll Cardiol. 2022 Mar 1;79(8):805-815. doi: 10.1016/j.jacc.2021.11.057. |
| 38404722 | Background | Zilla P, Human P, Pennel T. Mechanical valve replacement for patients with rheumatic heart disease: the reality of INR control in Africa and beyond. Front Cardiovasc Med. 2024 Feb 9;11:1347838. doi: 10.3389/fcvm.2024.1347838. eCollection 2024. |
| D001423 | Bacterial Infections and Mycoses |
| D007239 | Infections |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |