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| ID | Type | Description | Link |
|---|---|---|---|
| TYH2022225 | Other Grant/Funding Number | University of Helsinki | |
| TYH 2024332 | Other Grant/Funding Number | University of Helsinki | |
| TYH 2025382 | Other Grant/Funding Number | University of Helsinki | |
| Y2519SU010 | Other Grant/Funding Number | University of Helsinki |
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| Name | Class |
|---|---|
| University of Helsinki | OTHER |
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A human intervention study was performed to examine the antimicrobial effects of fermented lingonberry spray (FLJ spray) treatment, used for a period of 30 days.
Traditional clinical oral examinations, periodontal status and sample gatherings were performed at start point, two and four weeks. Bleeding on probing (BOP), visible plaque index (VPI), probing pocket depths (PPD) were examined and active-matrix metalloproteinase - 8 (aMMP-8) mouthrinse assays (Cutt-off 20 ng/ml) were carried out. Additionally, stimulated and resting saliva, pH and buffering capacity were tested as saliva test. A questionnaire assessing dry mouth symptoms was also recorded from the patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Adult patients were randomly selected from a private dental clinic in Tampere, Finland for the study | Experimental | Participants used approximately ten sprays four times a day (approx. 5,5 ml/ day) of FLJ-spray (Lingora® Oral Spray, Berries United Ltd, Helsinki, Finland) for a month. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Fermented lingonberry juice sprey | Other | Patented fermented lingonberry juice sprey |
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| Measure | Description | Time Frame |
|---|---|---|
| The effects of fermented lingonberry spray in the mouth. | Changes of bleeding on probing (BOP), from six measurement point, visible plaque index (VPI), score 1-3, probing pocket depths (PPD) and active-matrix metalloproteinase - 8 (aMMP-8) mouthrinse assays (Cutt-off 20 ng/ml), numerical value were carried out to one month. | Up to one month |
| the time points on the levels of each salivary parameter were determined with the repeated measures ANOVA analysis. | 6 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Helsinki | Tampere | 33100 | Finland |
All IPD collected throughout the trial.
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