Tacrolimus Eye Drops in Treatment of Vernal Keratoconjunctivitis

Efficacy and Safety of Tacrolimus Eye Drops in Treatment of Vernal Keratoconjunctivitis

The purpose of the study is to evaluate efficacy and safety of topical Tacrolimus eye drops in different concentrations in treatment of vernal keratoconjunctivitis (VKC) comparing it with Steroid based usual topical regimen

A hospital- based Prospective comparative randomized open label controlled trial . the study will be conducted on Patients with moderate to severe active VKC aged between (5-15) years old (pediatric age group). they will be divided into 2 groups control group will be treated with usual regimen ( steroid based) interventional group will be subdivided into 2 groups and each will be treated with Tacrolimus eye drops in 2 different concentrations

Follow up visits:

Will be scheduled 1st week , 2nd week then 4th week during the loading period Then every 2 weeks during the maintenance period Then monthly for another 3 months

Inclusion Criteria:

• Patients with moderate to severe active VKC aged between (5-15) years old (pediatric age group)

Exclusion Criteria:

1. Coexisting eye infections
2. Contact lens use
3. Systemic immunosuppressive drug use
4. Herpes keratitis
5. Recent ocular surgery or trauma
6. Known hypersensitivity to Tacrolimus
7. Ophthalmological comorbidities as cataract, glaucoma, and congenital eye anomalies
8. Impaired renal or hepatic functions