The purpose of this study is to understand how the body's immune cells respond to a new type of vaccine (neoantigen vaccine) designed to help the immune system recognize and fight cancer. To do this, the study team will collect a research specimen from participants to study their immune cells' reactions to the neoantigen vaccine. This research will help researchers learn more about how these vaccines might work to protect or treat against cancer.

Inclusion Criteria:

• Histologically confirmed current or previous solid malignancy or healthy individuals

• Willing to provide mandatory research blood draw or apheresis per protocol

• Provide written informed consent

• The following laboratory values obtained ≤ 28 days prior to registration

  • Hemoglobin ≥10.0 g/dl
  • Absolute neutrophil count (ANC) ≥1500/mm^3
  • Platelet count ≥100,000/mm^3

Exclusion Criteria:

• Any of the following prior therapies:

  • IV antibiotic ≤2 weeks prior to apheresis
  • Major Surgery ≤4 weeks prior to registration
  • Received a live vaccine ≤30 days prior to registration

• Active hematologic malignancies ≤ 3 years prior to registration

• Immunocompromised patients and patients known to be HIV positive and currently receiving antiretroviral therapy

• History of active tuberculosis (TB), human immunodeficiency virus (HIV), active hepatitis B (e.g., HBsAg reactive), and/or active hepatitis C infection [e.g., Hepatitis C Virus (HCV) ribonucleic acid (RNA) qualitative is detected)

• Known history of active autoimmune disease that has required systemic treatment in the ≤14 days (i.e., with the use of disease-modifying agents, corticosteroids >10 mg daily prednisone equivalent, or other immunosuppressive drugs) prior to registration.

  • NOTE: Replacement therapy (e.g., thyroxine, insulin, or physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency) is not considered a form of systemic treatment. Patients with vitiligo, Graves' disease, or psoriasis not requiring systemic treatment within the past 30 days are not excluded. Patients with Celiac disease controlled with diet modification are not excluded.

• Co-morbid systemic illnesses or other severe concurrent disease which, in the judgment of the investigator, would make the patient inappropriate for entry into this study or interfere significantly with the proper assessment of safety and toxicity of the prescribed regimens.

• Pregnancy](streamdown:incomplete-link)

Male and female participants who have/had cancer or are healthy individuals who would like to contribute to cancer research efforts.