A Phase 3 Study of VVN461 Ophthalmic Solution for Noninfectious Anterior Uveitis

A Multi-center, Randomized, Single-masked, Active-controlled Phase III Clinical Study to Evaluate the Efficacy and Safety of 1.0% VVN461 Ophthalmic Solution in Patients With Non-infectious Anterior Uveitis

This is a multicenter, randomized, single-masked, active-controlled, parallel, Phase III pivotal study in China

Inclusion Criteria:

• At the time of signing the informed consent form (ICF), the subject must be aged 18 to 70 years (inclusive);
• At screening, the affected eye is diagnosed with non-infectious anterior uveitis (acute or recurrent acute, only unilateral eye affected patients are included);
• At screening, the ACC grade of the affected eye is 2+ or 3+ [SUN criteria];
• At screening, the ACF grade of the affected eye is ≥1 [SUN criteria];

Exclusion Criteria:

• At screening, the affected eye has an ACC grade of 4+ or hypopyon
• Diagnosis of intermediate uveitis, posterior uveitis, or panuveitis in either eye at the time of screening