The current study evaluated the clinical effect and outcome of locally applied bee venom versus low-level laser therapy (LLLT) for the treatment of recurrent aphthous ulceration.

Recurrent aphthous stomatitis (RAS) is a Painful, idiopathic, and recurrent inflammatory ulceration of the oral cavity.

Despite their widespread use, prolonged or frequent application may result in adverse effects such as oral candida. In recent years, low-level laser therapy (LLLT) has gained attention as an alternative treatment for RAS.

Apitoxin has been used traditionally to treat a variety of conditions, such as arthritis, rheumatism, back pain, cancer, and skin diseases.

Inclusion Criteria:

• Age from 15 to 40 years old.
• Both sexes.
• No current or history of systemic medical problem.
• Non-smoker.
• Suffering from pain due to recurrent aphthous stomatitis (RAS) ulceration on the oral mucosa with the following characteristics:
• Duration of 2 days or less.
• The diameter ≥ 4mm
• Not been subjected to any treatment modalities for at least four weeks before the beginning of the study.

Exclusion Criteria:

• Presence of other oral mucosal ulcers other than RAS.
• Systemic disease that predisposed them to RAS (e.g., Behçet disease).
• Systemic medical problems.
• Pregnant, lactating, and postmenopausal patients.
• Smoker patients.
• Systemic or topical treatment for RAS less than four weeks before starting the study.
• Any earlier experiences of laser therapy.

The data will be available upon a reasonable request from the corresponding author after the end of study for one year.

After the end of study for one year.

The data will be available upon a reasonable request from the corresponding author.