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Based on previous studies, Both sildenafil and L-arginine helped to improve idiopathic oligohydramnios.
In this study, Level of improvment of oligohydramnios will be compared. As well as, NICU admission to neonates of pregnancies complicated by idiopathic oligohydramnios. The end goal is to help physicians use the best drug for their patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| sildn arm | Active Comparator | In this group, participants receive sildenafil 25 mg thrice a day. then amniotic fluid index is measured every week to measure its improvement. After delivery, APGAR will be measured. As well as, whether the fetus entered the NICU or not will be recorded. |
|
| L- argin arm | Active Comparator | In this group, participants receive L- arginine 1000 mg thrice a day. then amniotic fluid index is measured every week to measure its improvement. After delivery, APGAR will be measured. As well as, whether the fetus entered the NICU or not will be recorded. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Sildenafil 25 MG | Drug | Sildenafil is a vasodilator drug which improve blood supply to placenta.Therefore, it should improve idiopathic oligohydramnios. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Improvement of amniotic fluid index | Amniotic fluid index level measured before delivery. | two hours before cesarean section |
| Measure | Description | Time Frame |
|---|---|---|
| NICU admission | NICU admissions rate of the neonates in the study | first day after delivery |
| APGAR score | measuring APGAR score for the neonates in the study |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ibtesam T Gadalla, MBBch | Contact | 1025193157 | 0020 | bassmagadalla@gmail.com |
| Mostafa F El-lakany, PHD | Contact | 10116083210 | 0020 | Mfe_2014@yahoo.com |
| Name | Affiliation | Role |
|---|---|---|
| Dalia S Zolfakar, PHD | daliasamir94@gmail.com | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Kafrelsheikh University Hospital | Active, not recruiting | Kafr ash Shaykh | Kafrelsheikh | 33513 | Egypt | |
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| ID | Term |
|---|---|
| D016104 | Oligohydramnios |
| ID | Term |
|---|---|
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
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| ID | Term |
|---|---|
| D000068677 | Sildenafil Citrate |
| D001120 | Arginine |
| D013607 | Tablets |
| ID | Term |
|---|---|
| D013449 | Sulfonamides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D013450 | Sulfones |
| D013457 |
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| L-Arginine, 1000 Mg Oral Tablet | Drug | Aminoacid with vasodilator property which improve blood supply to placenta.Therefore, it should improve idiopathic oligohydramnios. |
|
|
| 5 minutes after delivery |
| Kafrelsheokh university hospital |
| Recruiting |
| Kafr ash Shaykh |
| Kafrelsheikh |
| 33513 |
| Egypt |
|
| Sulfur Compounds |
| D010879 | Piperazines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D011687 | Purines |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D024361 | Amino Acids, Basic |
| D000596 | Amino Acids |
| D000602 | Amino Acids, Peptides, and Proteins |
| D000599 | Amino Acids, Diamino |
| D000601 | Amino Acids, Essential |
| D004304 | Dosage Forms |
| D004364 | Pharmaceutical Preparations |