The aim of this study is to evaluate the efficacy of a topical cream infused with Scutellaria baicalensis extract in reducing hyperpigmentation on the face.

The study is experimental clinical pilot study as a single group pretest-posttest.

A ROAT is conducted 1 week prior to the experiment. Participant apply the cream on the hypigmented area daily. Facial skin parameters (i.e. melanin index, erythema index) is evaluated at week 0, 1, 2 and 4.

Inclusion Criteria:

• Male or Female
• Has at least 1 hyperpigmentation spot (size > 3mm) on either side of the face
• 30-60 y/o
• Fitzpatrick skin types II-IV
• Agrees to use sunscreen SPF50+ and willing to avoid strong sunlight exposure during the study

Exclusion Criteria:

• Pregnant or lactating
• Use of whitening products or treatment within 1 month before this study
• Currently using contraceptives
• History of allergy to any ingredient in the intervention cream
• Has skin conditions which can interfere with the measurement (i.e. severe acne, eczema, herpes simplex)
• Severe disease (i.e. immunodeficiency, cancer)
• Enrolled in other clinical study within 3 month before this study