Study of Efficacy and Safety of Cream Infused With HuangQin (Root of Scutellaria Baicalensis) Extract for the Reduction of Hyperpigmentation

Study of Efficacy and Safety of Cream Infused With HuangQin (Root of Scutellaria Baicalensis) Extract for the Reduction of Hyperpigmentation

The aim of this study is to evaluate the efficacy of a topical cream infused with Scutellaria baicalensis extract in reducing hyperpigmentation on the face.

The study is experimental clinical pilot study as a single group pretest-posttest.

A ROAT is conducted 1 week prior to the experiment. Participant apply the cream on the hypigmented area daily. Facial skin parameters (i.e. melanin index, erythema index) is evaluated at week 0, 1, 2 and 4.

Inclusion Criteria:

• Male or Female
• Has at least 1 hyperpigmentation spot (size > 3mm) on either side of the face
• 30-60 y/o
• Fitzpatrick skin types II-IV
• Agrees to use sunscreen SPF50+ and willing to avoid strong sunlight exposure during the study

Exclusion Criteria:

• Pregnant or lactating
• Use of whitening products or treatment within 1 month before this study
• Currently using contraceptives
• History of allergy to any ingredient in the intervention cream
• Has skin conditions which can interfere with the measurement (i.e. severe acne, eczema, herpes simplex)
• Severe disease (i.e. immunodeficiency, cancer)
• Enrolled in other clinical study within 3 month before this study