Perioperative pain management in craniotomy requires the administration of effective regional anesthetic techniques to reduce the use of systemic opioids and optimize hemodynamic control. Scalp block has been demonstrated to suppress hemodynamic response; however, its implementation generally involves a large number of injection points (six nerves that must be blocked bilaterally, resulting in a total of 12 injection points) and the possibility that not all nerve points are adequately blocked. Meanwhile, superficial cervical plexus and supraorbital block involves fewer injection points (two nerves to be blocked bilaterally, for a total of four injection points) with an analgesia area that may be sufficient to facilitate craniotomy surgery, including the insertion of Mayfield pins, consisting of only three pins, where the pin insertion area is not too large. The objective of this study is to compare the efficacy of combined superficial cervical plexus and supraorbital block with scalp block in reducing intraoperative opioid consumption and controlling hemodynamic response in craniotomy surgery.

Inclusion Criteria:

1. The patient has been scheduled to undergo a craniotomy procedure that has been deemed medically necessary and electively scheduled. The aforementioned procedure will be performed under the administration of general anesthesia and the utilization of Mayfield pins.
2. Adult patients who have reached an age of 18 years and have not yet reached 65 years of age are included in this study.
3. Patients with ASA classification 1 - 3
4. The patient has expressed their willingness to participate in a research study and has provided their signature on an informed consent form.

Exclusion Criteria:

1. The patient has been diagnosed with an infection in the area where the block needle insertion is to be performed.
2. The subjects of this study were patients with a body mass index (BMI) greater than 30 kg/m2 who were classified as Grade II obese.
3. The patient is currently undergoing treatment with a beta-blocker.
4. Patients in whom intraoperative evoked potential monitoring is scheduled.
5. The patient is scheduled to undergo a total intravenous anesthesia technique
6. The history of an allergy to local anesthesia is presented before.