Effect of a Simplified Mindfulness Intervention on Health-related Quality of Life in Patients Undergoing Hematopoietic Stem Cell Transplantation: A Prospective Single-Center Randomized Controlled Trial

Effect of a Simplified Mindfulness Intervention on Health-related Quality of Life in Patients Undergoing Hematopoietic Stem Cell Transplantation: A Prospective Single-Center Randomized Controlled Trial

This study aims to evaluate the impact of a simplified mindfulness intervention (daily mindfulness breathing and body scanning) during hospitalization in the transplant ward on health-related quality of life in hematopoietic stem cell transplantation patients.

All patients undergo standardized HSCT treatment, which does not interfere with the management of their underlying conditions. Patients are randomly assigned to either the 'Mindfulness Intervention Group' or the 'Conventional Support Group' based on age (whether over 40) and transplant type (autologous or allogeneic), in a 1:1 ratio. The study period is at least 21 days, during which patients are hospitalized in the transplant ward.

Inclusion Criteria:

1. Aged 18 years or older.
2. Scheduled to receive either autologous or allogeneic HSCT.
3. Anticipated inpatient stay in the transplant unit of at least 21 days.

Exclusion Criteria:

1. Prior history of hematopoietic stem cell transplantation (HSCT).
2. Active psychiatric disorder or cognitive impairment.
3. Systematic training in mindfulness/mindfulness-based interventions/yoga within the past 3 months.
4. Contraindications to MRI.