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This study aims to evaluate the impact of a simplified mindfulness intervention (daily mindfulness breathing and body scanning) during hospitalization in the transplant ward on health-related quality of life in hematopoietic stem cell transplantation patients.
All patients undergo standardized HSCT treatment, which does not interfere with the management of their underlying conditions. Patients are randomly assigned to either the 'Mindfulness Intervention Group' or the 'Conventional Support Group' based on age (whether over 40) and transplant type (autologous or allogeneic), in a 1:1 ratio. The study period is at least 21 days, during which patients are hospitalized in the transplant ward.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Mindfulness intervention group | Experimental | 1. Mindfulness intervention group: Intermittent period: from the first day to at least the 21st day, and up to the 28th day, continuous implementation Content of intervention (daily completion):
|
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| Conventional support group | No Intervention | received conventional nursing and rehabilitation guidance, but did not receive mindfulness intervention. The control group patients received conventional hospital nursing services during the study period, including disease monitoring, drug treatment, rehabilitation guidance, etc., but did not receive any form of mindfulness training or other similar psychological interventions. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Mindfulness intervention | Behavioral | Intermittent period: from the first day to at least the 21st day, and up to the 28th day, continuous implementation Content of intervention (daily completion):
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in FACT-BMT Score (Δ Score) | The daily trajectory of FACT-BMT total scores during hospitalization will be continuously monitored in both the mindfulness intervention group and the routine support group. The difference between the lowest daily score and the baseline score (Δ nadir) will be calculated to reflect the maximum decline in quality of life during hospitalization. A comparison will be made between the two groups to determine whether there is a difference in the maximum reduction of FACT-BMT total scores during hospitalization, thereby evaluating the mitigating effect of mindfulness intervention on the deterioration of quality of life. | baseline to Day 28 |
| Measure | Description | Time Frame |
|---|---|---|
| Change in HADS score | Assessing trends in emotional improvement. | Baseline, Day 28 |
| EQ-5D-5L score | Includes 5-dimensional scores and Visual Analog Scale (VAS) ratings to reflect subjective health status |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| erlie jiang, doctor | Contact | 02223608600 | jiangerlie@ihcams.ac.cn |
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| baseline ,Day 28 |
| MoCA cognitive function | Evaluating cognitive performance. | baseline ,Day 28 |
| MRI structural changes | Hippocampal volume, dorsolateral prefrontal cortex (DLPFC) thickness, and surface area | Day 0, Day 28 |
| Incidence of bloodstream bacterial infections in the transplant unit | Including the number of positive bacterial blood cultures | From Day 0 through discharge |
| Post-Traumatic Growth Inventory (PTGI) | Assessing the degree of personal growth following traumatic experiences | baseline, Day 28 |
| Subjective Well-Being Scale (SWB) | Measuring life satisfaction and quantifying emotional experiences | baseline, Day 28 |
| Pittsburgh Sleep Quality Index (PSQI) | Quantifying sleep quality | baseline, Day 28 |