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This study aims to develop the deep learning-based system that integrates multimodal information to automatically diagnose, stage, and grade thyroid-associated ophthalmopathy (TAO), assist in treatment decision-making, and predict patient prognosis, thereby providing novel tools to support clinical management.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Participants without Thyroid-associated ophthalmopathy | Participants without thyroid-associated ophthalmopathy based on Bartley criteria. |
| |
| Patients with Thyroid-associated ophthalmopathy | Patients diagnosed as thyroid-associated ophthalmopathy based on Bartley criteria. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Imaging and ocular examinations | Other | 2D and 3D Facial photography, blinking videos, orbital CT and MRI images, fundus images and images of nine gaze positions are taken. Clinical information is recorded. Quality of life is assessed. Ocular examinations, such as visual acuity, levator function, exophthalmos measurement, strabismus test, visual field examination, axial length measurement, OCT, OCTA are made. |
| Measure | Description | Time Frame |
|---|---|---|
| eye morphological parameters | Margin reflex distances(mm) | through study completion, average of 5 years |
| Blinking feature of patients with thyroid-associated ophthalmopathy | Blinking frequency | through study completion, average of 5 years |
| Ocular movement measurement | Ocular movement ability in nine gaze positions | through study completion, average of 5 years |
| Automatic orbital structures segmentation and measurement using deep learning methods | Automatic segmentation and measurement of orbital structures,such as eyeball, extraocular muscle, orbital fat, bony orbital region, optic nerves, etc | through study completion, average of 5 years |
| Automatic diagnosis, grading, staging and prediction of patients with thyroid-associated ophthalmopathy | Patients with thyroid-associated ophthalmopathy(TAO) are classified as TAO or non-TAO. Grading is classified as mild, moderate, severe and sight-threatening. Staging is classified as active and stable. | through study completion, average of 5 years |
| three-dimensional eye parameters | eyelid volume | through study completion, average of 5 years |
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Inclusion Criteria:
Exclusion Criteria:
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500 patients with thyroid-associated ophthalomopahty 500 patients without thyroid-associated ophthalomopahty
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Juan Ye | Contact | +86-571-87783897 | yejuan@zju.edu.cn |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Juan Ye | Recruiting | Hangzhou | Zhejiang | 310000 | China |
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| ID | Term |
|---|---|
| D049970 | Graves Ophthalmopathy |
| ID | Term |
|---|---|
| D015785 | Eye Diseases, Hereditary |
| D005128 | Eye Diseases |
| D006111 | Graves Disease |
| D005094 | Exophthalmos |
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| ID | Term |
|---|---|
| D014965 | X-Rays |
| ID | Term |
|---|---|
| D060733 | Electromagnetic Radiation |
| D055590 | Electromagnetic Phenomena |
| D060328 | Magnetic Phenomena |
| D055585 | Physical Phenomena |
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|
| D009916 |
| Orbital Diseases |
| D030342 | Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D006042 | Goiter |
| D013959 | Thyroid Diseases |
| D004700 | Endocrine System Diseases |
| D006980 | Hyperthyroidism |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |
| D011827 | Radiation |
| D011839 | Radiation, Ionizing |