Not provided
Not provided
| ID | Type | Description | Link |
|---|---|---|---|
| Sal001 | Other Identifier | Liaquat University of Medical and Health Sciences |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| Sindh Higher Education Commission | UNKNOWN |
Not provided
Not provided
Not provided
Not provided
Oral cancer is the top cancer in Pakistan, accounting for 27%, and it has a high mortality rate due to late-stage diagnosis. It primarily affects the lips, tongue, cheeks, and floor of the mouth. Major risk factor for oral cancer development is pan supari chhaliya chewing.
Patients often develop a pre-malignant condition, oral submucous fibrosis, resulting in limited mouth opening. Thus, patients are diagnosed at an advanced level and poor survival. Therefore, saliva appears a potential mode of evaluation for early detection. This project aims to evaluate salivary cells, genes and biochemistry of the saliva among health volunteers and compare it with that of the patients with oral submucous fibrosis and oral cancer.
The project aims to evaluate salivary cytology, genes and biochemistry of the healthy normal population and compare it with that of the oral submucous fibrosis and oral cancer. For salivary experiments 3 cc of fresh saliva will be collected and analysed.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Normal healthy volunteers | oral examination will be done, those without any oral infection, oral submucous fibrosis or cancer will be included in health volunteer group |
| |
| oral submucous fibrosis | Patients with oral submucous fibrosis both with and without limited mouth opening |
| |
| oral cancer patients | patients with biopsy proven oral cancer |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| saliva a a diagnostic tool for early detection of oral cancer | Diagnostic Test | Three groups will be compared on the basis of cytology, genes and biochemical analysis |
|
| Measure | Description | Time Frame |
|---|---|---|
| salivary cytology | A method will be developed for evaluation of detection of oral cancer | 1 year |
| evaluation of telomere length of salivary cells | Telomere length will be evaluation in the saliva of three groups | 1 year |
| evaluation of biochemicals of saliva | saliva of three groups will be compared on the basis of salivary enzymes | 1 year |
Not provided
| Measure | Description | Time Frame |
|---|---|---|
| A scoring system will be developed for the screening of patients at risk of oral submucous fibrosis | A scoring system will be developed including cytology, genetic and biochemistry and algorithm will be designed for accurate assessment of the oral cancer | 2 years |
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
The three groups will be recruited: healthy volunteers with unremarkable oral examination, patients with oral submucous fibrosis regardless of mouth opening and biopsy proven oral cancer patients.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Binafsha Manzoor Prof, SYed, PhD | Contact | 00923332749201 | binafsha.syed@lumhs.edu.pk | |
| Fasiha Dr Shah, PhD | Contact | 00923363019144 | fasiha.shah@lumhs.edu.pk |
| Name | Affiliation | Role |
|---|---|---|
| Binafsha Manzoor Prof. Syed, PhD | Liaquat University of Medical and Health Sciences | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Medical Research Center | Recruiting | Jāmshoro | Sinch | Pakistan |
IPD includes: Group, age, gender, smoking status, oral hygiene status, saliva collection date, salivary cytology parameters, telomere length, p53 status
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided