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| ID | Type | Description | Link |
|---|---|---|---|
| BRWEP2024W022040104 | Other Grant/Funding Number | Beijing Municipal Health Commission |
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Cerebral arteriovenous malformation (AVM) is the leading cause of brain hemorrhage in young adults, characterized by sudden onset and rapid progression. The hybrid neurosurgical operating room is a diagnostic and therapeutic platform that integrates neurointervention and microneurosurgery, offering advantages such as one-stop rapid treatment and multimodal therapeutic approaches.
This study aims to focus on patients with acute cerebral AVM-related hemorrhage through a multicenter, prospective, registry-based research approach. In the hybrid neurosurgical operating room, emergency cerebral angiography, neurointerventional embolization, microsurgical resection of the vascular malformation, or minimally invasive hematoma evacuation will be performed to explore the indications and advantages of the hybrid neurosurgical operating platform in emergency AVM hemorrhage management. The study seeks to establish standardized diagnostic and treatment protocols and operational workflows for emergency AVM hemorrhage management in the hybrid operating room. Through continuous quality improvement, the study aims to further reduce patient morbidity and mortality.
This research will not only enhance the diagnostic and therapeutic level of cerebral AVM-related hemorrhage and improve patient outcomes but also effectively reduce medical costs and societal burdens.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Hybrid surgery cohort | After patients were enrolled, they were admitted to the hybrid operating room for DSA to confirm the diagnosis. If the patient meets the surgical indications, one-stop treatment with composite surgery will be performed. During the operation, the treatment plan is determined based on the characteristics of the malformation group, including simple embolization, partial embolization, auxiliary embolization for arteriovenous malformation resection, and the target area and proportion of embolization. For those who need craniotomy, the hematoma is removed during the operation and the brain arteriovenous malformation is removed under a microscope. Intraoperative ultrasound assists in locating the location, boundaries and residue of the malformation. Head DSA was reviewed immediately after surgery. Further clarify whether the lesions are completely removed. If the lesion remains, immediate surgical treatment and subsequent DSA review will be perfor |
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| Measure | Description | Time Frame |
|---|---|---|
| Neurological outcomes | modified rankin scale (mRS), The scale runs from 0-6. Higher scores mean a worse outcome | 2 weeks, 3 months, 6 months after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| surgical information | pre-surgery, during the surgery, perioperatively immediately after the surgery | |
| Complications | 2 weeks, 3 months, 6 months after surgery |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with mergency cerebral arteriovenous malformation bleeding
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Yuming Jiao, MD | Contact | 86-15010108242 | shengxiongyuming@163.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Beijing Tiantan Hospital, Capital Medical University | Recruiting | Beijing | 100070 | China |
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| ID | Term |
|---|---|
| D001165 | Arteriovenous Malformations |
| D006470 | Hemorrhage |
| D002543 | Cerebral Hemorrhage |
| D002538 | Intracranial Arteriovenous Malformations |
| ID | Term |
|---|---|
| D054079 | Vascular Malformations |
| D018376 | Cardiovascular Abnormalities |
| D002318 | Cardiovascular Diseases |
| D014652 | Vascular Diseases |
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| D000013 | Congenital Abnormalities |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D020300 | Intracranial Hemorrhages |
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D020785 | Central Nervous System Vascular Malformations |
| D009421 | Nervous System Malformations |
| D020765 | Intracranial Arterial Diseases |