Rationale: To determine the plasma lycopene concentration before and after an oral intake of lycopene in order to use this measurement as a life style compliance marker.

Objective: Primary objective: to determine if a plasma lycopene concentration can serve as a response parameter after a single dose of dietary lycopene.

Study design: Cross-over interventional pilot study.

Study population: Ten male healthy volunteers 18-75 years. Intervention: Oral food supplement tablet 40 mg lycopene once, versus oral soup of cooked tomatoes equivalent to 40 mg lycopene content. In addition, the participants' habitual diet and actual food intake during the intervention will be measured using a food frequency questionnaire and a food diary.

Main study parameters/endpoints: Variation of plasma lycopene 1 hour before, and 1,3,6,12,24,48,72 hours after intervention.

Nature and extent of the burden and risks associated with participation, benefit and group relatedness: Eight blood samples of 6 ml full venous blood obtained by vena puncture per intervention per individual, 2 times in a cross-over pilot study, in which interventions are 3 weeks apart (so 2 x 8 samples in 10 volunteers). Risk of vena puncture is negligible, idemque the burden.

Inclusion Criteria:

• Male;
• Healthy;
• 18-75 yrs old.

Exclusion Criteria:

• Allergic for tomatoes;
• Any gastrointestinal disorder within 3 months prior to the intervention;
• Recent medication or supplement use;
• Recent substantial change in weight;
• Adherence to a specific diet ( for example the Moorman-diet);
• Using recreational drugs more than once a month;
• Smoking and excessive alcohol consumption (>10 standardized glasses a week).
• Risk of a dependency situation with the researchers.

Males by birth.