The Role of POLE Mutation in High Risk Endometrial Cancer.

The Role of POLE Mutation in High Risk Endometrial Cancer.

The actual role of POLE mutations in high-risk endometrial cancer is undetermined. The main question it aims to answer is:

What is the prevalence of POLE mutations in high-risk endometrial cancer case? What is the impact of POLE mutations in real world high-risk endometrial cancer case?

All high-risk recurrent endometrial cancer cases who were treated in a tertiary referral center will be analyzed and subjected to POLE mutation analysis. In addition, survival analysis will be used to analyze the role of POLE mutations in women with high-risk endometrial cancer. We can answers the following.

1. What is the prevalence of POLE mutations in women with high-risk endometrial cancer?
2. What is the role of POLE mutations in real world high-risk endometrial cancer?

Inclusion Criteria:

• women with high-risk for recurrent endometrial cancer

Exclusion Criteria:

• Nil