New Topical Treatment in Plaque Psoriasis | NCT07113756 | Trialant

New Topical Treatment in Plaque Psoriasis | NCT07113756 | Trialant

Arms/Interventions Module

Arm Groups

Label	Type	Description	Intervention Names
group (1) will use topical metformin 30% cream	Active Comparator	each patient will use topical metformin 30% cream twice daily for 12 weeks. o Preparation of metformin 30% cream: Weighing 30 gm standard metformin ( E. Merck ) supplied by chemtech. Using digital balance then Grinding the powder by pestle & Morter then Adding 30 ml propylene glycol and alcohol to reach a total 100 gm weight then adding parabens mix as preservative with 0.5 gm then mix thoroughly followed by Levegating & mixing then divide to smaller well tighten closure with labels	Drug: topical metformin 30% cream
group(2) topical betamethasone valerate .1% cream.	Placebo Comparator	each patient will use topical betamethasone valerate .1% cream twice daily for 12 weeks.	Drug: betamethasone valerate.1% cream

Interventions

Name	Type	Description	Arm Group Labels	Other Names
topical metformin 30% cream	Drug	each patient will use topical metformin 30% cream twice daily for 12 weeks. o Preparation of metformin 30% cream: Weighing 30 gm standard metformin ( E. Merck ) supplied by chemtech. Using digital balance then Grinding the powder by pestle & Morter then Adding 30 ml propylene glycol and alcohol to reach a total 100 gm weight then adding parabens mix as preservative with 0.5 gm then mix thoroughly followed by Levegating & mixing then divide to smaller well tighten closure with labels

Outcomes Module

Primary Outcomes

Measure	Description	Time Frame
clinical improvement in psoriatic skin lesions	clinical evaluation using PASI score to assess improvement before and treatment	at the end of treatment (12 weeks) and 3 months after stoppage of treatment

Contacts/Locations Module

Intervention Browse Module