Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
This retrospective cross-sectional study evaluated the safety and effectiveness of the fundus-first laparoscopic cholecystectomy (FFLC) technique in patients with difficult gallbladders. A total of 124 patients who underwent FFLC between 2023 and 2024 were reviewed. The study assessed operative time, intraoperative complications, conversion rates, and postoperative outcomes. The results suggest that FFLC is a safe and feasible approach that can reduce the need for conversion to open surgery in complex cases. The study was conducted at a private hospital in Istanbul, Turkey
This retrospective study was conducted at a private healthcare institution without a formal IRB. All patient data were anonymised before analysis, and written informed consent was obtained from all patients for the academic use of their clinical data
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Conventional Laparoscopic Cholecystectomy | Patients who underwent standard laparoscopic cholecystectomy, starting dissection at Calot's triangle. This technique served as the comparator for assessing safety and conversion rates relative to the fundus-first approach. |
| |
| Fundus-First Laparoscopic Cholecystectomy | Patients with difficult gallbladders (Nassar Grade 3-4) who underwent laparoscopic cholecystectomy using the fundus-first technique. This approach involved starting dissection at the gallbladder fundus and proceeding retrogradely toward Calot's triangle to improve safety in complex cases. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Conventional Laparoscopic Cholecystectomy | Procedure | Standard laparoscopic cholecystectomy technique starting at Calot's triangle. Used as the comparator group in this study. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Conversion Rate to Open Surgery | Rate of conversion from laparoscopic to open cholecystectomy in each group. Measured as number and percentage of patients converted. | Intraoperative (during surgery) |
| Measure | Description | Time Frame |
|---|---|---|
| Operative Time | Total operative time measured in minutes from skin incision to closure. Comparison between the fundus-first and conventional laparoscopic cholecystectomy groups. | Intraoperative (during surgery) |
| Postoperative Complication Rate |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
This study included adult patients (≥18 years) who underwent laparoscopic cholecystectomy for difficult gallbladder (Nassar grade 3-4) at a single tertiary care center between January 2023 and March 2024.
Not provided
| Name | Affiliation | Role |
|---|---|---|
| KANAN ISMAYILZADA, MD | Medicana Ataşehir International Hospital, ISTANBUL.TURKEY | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Medicana Ataşehir International Hospital | Istanbul | Ataşehir | 34750 | Turkey (Türkiye) |
The study is retrospective in nature, and no plans have been made to share individual participant data with other researchers.
Not provided
Not provided
Not provided
Not provided
Not provided
| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot | Yes | No | No | Study Protocol | Aug 2, 2025 | Aug 2, 2025 | Prot_000.pdf |
Not provided
| ID | Term |
|---|---|
| D002769 | Cholelithiasis |
| ID | Term |
|---|---|
| D001660 | Biliary Tract Diseases |
| D004066 | Digestive System Diseases |
Not provided
Not provided
Not provided
Not provided
Not provided
|
| Fundus-First Laparoscopic Cholecystectomy | Procedure | Laparoscopic cholecystectomy technique initiated at the gallbladder fundus and carried out retrogradely toward Calot's triangle. This method was applied to difficult gallbladders (Nassar Grade 3-4) to improve operative safety and avoid conversion to open surgery. |
|
|
Includes complications such as wound infection, bile leak, abscess, or any adverse event requiring medical or surgical intervention. Compared between groups
| Within 30 days postoperatively |
| Length of Hospital Stay | Number of days from surgery to discharge. Mean values will be compared between groups. | Postoperative hospitalization |