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In this research project, we want to investigate whether the combined intake of proteins and tea extract has an influence on muscle regeneration compared to the sole intake of proteins or a placebo product. In the study, you will be randomly assigned to one of 3 groups. Neither the research group nor you will know which group you are assigned to. The study lasts 5 days for you as a participant. During these 5 days you will have to attend a total of 5 appointments in our laboratory. The groups differ only in the intake of the regeneration product, otherwise all measurements and appointments are identical. You will jog downhill for 30 minutes on the first day in order to strain your muscles. In order to be able to draw conclusions about the regeneration of your muscles, we will carry out the following measurements on all 5 days: Blood sampling at the fingertip, ultrasound of the thigh muscle, pain tolerance of the thigh muscle, strength tests of the thigh muscle, muscle function of the thigh muscle and jumping performance.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Protein and tea extract | Experimental | This group will receive a recovery drink containing protein and tea extract. |
|
| Protein | Active Comparator | This group will receive a recovery drink containing protein without tea extract. |
|
| Placebo | Placebo Comparator | This group will receive a recovery drink containing a placebo product. The placebo product is a non-isoenergetic, non-protein, artificially flavoured liquid. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Protein and tea extract | Dietary Supplement | Participants in this group will receive 4 times a recovery drink containing protein and tea extract. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in maximum knee extension force immediately after training-induced muscle damage and 24, 48, 72, and 96 hours thereafter compared to baseline. | The maximal force is measured in Nm while the participant is seated on an isokinetic device. | 5 days |
| Change in jump performance immediately after training-induced muscle damage and 24, 48, 72, and 96 hours thereafter compared to baseline. | The jump performance is measured in cm while the participant are performing counter movement jumps. | 5 days |
| Change in perceived pain immediately after training-induced muscle damage and 24, 48, 72, and 96 hours thereafter compared to baseline. | Perceived pain is measured in Pa while the participant is seated on the isokinetic device. The measurement point is on vastus medialis muscle. | 5 days |
| Change in muscle thickness immediately after training-induced muscle damage and 24, 48, 72, and 96 hours thereafter compared to baseline. | Muscle thickness is measured with b-mode ultrasound in mm while the participant is sitting on the isokinetic device. The measurement point is on the vastus medialis muscle. | 5 days |
| Change in creatine kinase levels immediately after exercise-induced muscle damage and 24, 48, 72, and 96 hours thereafter compared to baseline. | Creatine kinase is measured in U/L and determined using a capillary finger blood sample of 0.25 ml. | 5 days |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Sven Egger, Dr. | Contact | +41 26 300 72 85 | sven.egger@unifr.ch | |
| Benedikt Lauber, PD Dr. | Contact | +41 26 300 72 86 | benedikt.lauber@unifr.ch |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Fribourg | Recruiting | Fribourg | Canton of Fribourg | 1700 | Switzerland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36900433 | Result | Volpe-Fix AR, de Franca E, Silvestre JC, Thomatieli-Santos RV. The Use of Some Polyphenols in the Modulation of Muscle Damage and Inflammation Induced by Physical Exercise: A Review. Foods. 2023 Feb 21;12(5):916. doi: 10.3390/foods12050916. | |
| 30804809 | Result | Isaacs AW, Macaluso F, Smith C, Myburgh KH. C-Reactive Protein Is Elevated Only in High Creatine Kinase Responders to Muscle Damaging Exercise. Front Physiol. 2019 Feb 11;10:86. doi: 10.3389/fphys.2019.00086. eCollection 2019. |
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It is planned that only our research group will analyze and publish the data. Therefore, the data will not be passed on to other researchers.
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| ID | Term |
|---|---|
| D011506 | Proteins |
| D013662 | Tea |
| ID | Term |
|---|---|
| D000602 | Amino Acids, Peptides, and Proteins |
| D028321 | Plant Preparations |
| D001688 | Biological Products |
| D045424 | Complex Mixtures |
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randomized, double-blinded, placebo-controlled.
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| Protein | Dietary Supplement | Participants of this group will receive ten times a recovery drink containing only protein without tea extract. |
|
| Placebo | Dietary Supplement | Participants of this group will receive 10 times a placebo containing no protein nor tea extract. |
|
| 33838590 | Result | Hug F, Avrillon S, Del Vecchio A, Casolo A, Ibanez J, Nuccio S, Rossato J, Holobar A, Farina D. Analysis of motor unit spike trains estimated from high-density surface electromyography is highly reliable across operators. J Electromyogr Kinesiol. 2021 Jun;58:102548. doi: 10.1016/j.jelekin.2021.102548. Epub 2021 Mar 30. |
| 3614975 | Result | Fischer AA. Pressure algometry over normal muscles. Standard values, validity and reproducibility of pressure threshold. Pain. 1987 Jul;30(1):115-126. doi: 10.1016/0304-3959(87)90089-3. |
| 30727028 | Result | Del Vecchio A, Casolo A, Negro F, Scorcelletti M, Bazzucchi I, Enoka R, Felici F, Farina D. The increase in muscle force after 4 weeks of strength training is mediated by adaptations in motor unit recruitment and rate coding. J Physiol. 2019 Apr;597(7):1873-1887. doi: 10.1113/JP277250. Epub 2019 Feb 6. |
| 38195943 | Result | Coratella G, Varesco G, Rozand V, Cuinet B, Sansoni V, Lombardi G, Vernillo G, Mourot L. Downhill running increases markers of muscle damage and impairs the maximal voluntary force production as well as the late phase of the rate of voluntary force development. Eur J Appl Physiol. 2024 Jun;124(6):1875-1883. doi: 10.1007/s00421-023-05412-z. Epub 2024 Jan 10. |
| 23908313 | Result | Botter A, Vieira TM, Loram ID, Merletti R, Hodson-Tole EF. A novel system of electrodes transparent to ultrasound for simultaneous detection of myoelectric activity and B-mode ultrasound images of skeletal muscles. J Appl Physiol (1985). 2013 Oct 15;115(8):1203-14. doi: 10.1152/japplphysiol.00090.2013. Epub 2013 Aug 1. |
| D001628 | Beverages |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
| D019602 | Food and Beverages |