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| ID | Type | Description | Link |
|---|---|---|---|
| LF_2023_0118 | Other Identifier | Faculty of Medicine, Palacky University, Olomouc, Czechia |
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The prospective study will focus on patients undergoing multimodal treatment for rectal cancer. The main objective of the study will be to monitor changes in circulating tumor cells (CTCs) in the peripheral blood of patients during multimodal treatment. For each patient enrolled in the study, peripheral blood samples will be collected at specified time intervals to determine the presence and quantity of CTCs.
The CTCs levels will be compared among rectal cancer patients with neoadjuvant chemoradiotherapy and without neoadjuvant chemotherapy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Rectal cancer patients with neoadjuvant chemoradiotherapy | |||
| Rectal cancer patients without neoadjuvant chemoradiotherapy |
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| Measure | Description | Time Frame |
|---|---|---|
| Levels of circulating tumor cells in peripheral blood | The levels of circulating tumor cells will be measured in rectal cancer patients | The levels of circulating tumor cells will be measured in 5 time points: before neoadjuvant chemoradiotherapy, in 3. week of chemoradioterapy, before surgery, one week after surgery and one month after surgery. |
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Inclusion Criteria: rectal cancer -
Exclusion Criteria: no other cancer
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Rectal cancer patients
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Josef Srovnal, Associate professor, MD, PhD | Contact | +420 585632137 | josef.srovnal@upol.cz |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital Ostrava | Recruiting | Ostrava | Czechia |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38302423 | Background | Ihnat P, Srovnal J, Hrubovcak J, Martinek L. Detection and clinical significance of circulating tumour cells in patients with colorectal carcinoma. Rozhl Chir. 2023;102(10):376-380. doi: 10.33699/PIS.2023.102.10.376-380. |
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Patients code; sex; age; diagnosis; clinical, laboratory and experimental findings
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| ID | Term |
|---|---|
| D009360 | Neoplastic Cells, Circulating |
| ID | Term |
|---|---|
| D009362 | Neoplasm Metastasis |
| D009385 | Neoplastic Processes |
| D009369 | Neoplasms |
| D010335 | Pathologic Processes |
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Peripheral blood
| D013568 |
| Pathological Conditions, Signs and Symptoms |