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| Name | Class |
|---|---|
| Antalya Bilim University | OTHER |
| Hacettepe University | OTHER |
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Chronic Obstructive Pulmonary Disease (COPD) is a progressive condition marked by airflow limitation and chronic inflammation, leading to reduced exercise capacity, peripheral muscle dysfunction, and dyspnea. High-Intensity Interval Training (HIIT) may offer a promising alternative for patients with low exercise tolerance; however, evidence on its effectiveness remains limited.
This study aims to compare the effects of HIIT and Moderate-Intensity Continuous Training (MICT) on muscle oxygenation, pulmonary function, exercise capacity, and peripheral muscle strength in individuals with COPD. Participants will undergo an 8-week exercise program, twice weekly. HIIT will consist of 1-minute intervals at 90% and 30-40% of peak workload, while MICT will involve continuous cycling at 65% of peak workload. Outcomes will be assessed at baseline, week 4, and week 8. Data will be analyzed using SPSS. This study seeks to determine the more effective training modality to optimize COPD rehabilitation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control Group | Active Comparator | standard aerobic exercise will apply in moderate intensity continuous training. |
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| interval exercise group | Experimental |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| HIIT GROUP | Other | Participants will perform a 31-minute protocol on a cycle ergometer consisting of 1-minute high-intensity intervals at 90% of peak workload (W peak) and low-intensity intervals at 30-40% of W peak, twice a week for 8 weeks. |
| Measure | Description | Time Frame |
|---|---|---|
| Peripheral and Respiratory Muscle Oxygenation | Muscle oxygenation will be measured using Near-Infrared Spectroscopy from the dominant quadriceps (peripheral) and 7th intercostal space (respiratory) during rest, warm-up, exercise, recovery phases, and 5 minutes post-exercise. Parameters include SmO₂_basal, SmO₂_max, SmO₂_min, SmO₂_maxrec, ∆SmO₂_max, SmO₂_deox, SmO₂_reoxy, and ∆SmO₂_maxrec. | at the baseline, at the 4th week, at the end of the 8th week. |
| Measure | Description | Time Frame |
|---|---|---|
| Pulmonary Function test | Pulmonary function will be evaluated using spirometry in accordance with ATS/ERS guidelines. the outcomes presented as liter/minute. | at the baseline, at the 4th week, at the end of the 8th week. |
| Functional Exercise Capacity |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Aynur Demirel, PT, PhD, Assoc. Prof. | Contact | +903051576168 | aynur.demirel@hacettepe.edu.tr | |
| Irem Suzen, PT MsC | Contact | +905393260706 | irem.suzen@antalya.edu.tr |
| Name | Affiliation | Role |
|---|---|---|
| Fulsen Bozkus, MD., Prof. | Sağlık Bilimleri University Antalya Health Application and Research Center | Study Director |
| Aynur Demirel, PT, PhD, Assoc. Prof. | Hacettepe University | Principal Investigator |
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| ID | Term |
|---|---|
| D029424 | Pulmonary Disease, Chronic Obstructive |
| ID | Term |
|---|---|
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D002908 | Chronic Disease |
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HIIT or MICT will be applied in patients with COPD groups.
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Statistical Analyzer will be masked.
| MICT | Other | Moderate intensity continous exercise |
|
Functional exercise capacity will be assessed using the 6-Minute Walk Test (6MWT) according to ATS guidelines.
| at the baseline, at the 4th week, at the end of the 8th week. |
| Dyspnea | Dyspnea will be assessed using the Modified Medical Research Council (mMRC) Dyspnea Scale, a 5-point ordinal scale evaluating activity-induced breathlessness. | at the baseline, at the 4th week, at the end of the 8th week. |
| Upper extremity Muscle Strength | Upper extremity will measure by hand dynomometer. The highest grip force will be recorded as kilograms. | at the baseline, at the 4th week, at the end of the 8th week. |
| Activities of Daily Living | Activity limitation due to dyspnea will be assessed by the London Chest Activity of Daily Living Scale (LCADL). Total and subscale scores will be analyzed (range: 0-75). | at the baseline, at the 4th week, at the end of the 8th week. |
| Health-Related Quality of Life | Quality of life will be evaluated using the St. George's Respiratory Questionnaire (SGRQ). Total and subscale scores (Symptoms, Activity, Impacts) will be recorded (range: 0-100). | at the baseline, at the 4th week, at the end of the 8th week. |
| Comorbidities | Comorbidity burden will be assessed using the Charlson Comorbidity Index (CCI) | at the baseline, at the 4th week, at the end of the 8th week. |
| lower extremity endurance test | 30 second chair stand test will use. The number of repetitions will be recorded. | at baseline, at the 4th week and at the end of 8th week. |
| D020969 |
| Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |