1. Clinical and/or laboratory signs of chorioamnionitis will result in an intervention consisting of the course of antenatal steroids (if not already administered, or as a single course prior 34+0 if at least 7 days have passed after the previous course), initial broad spectrum antibiotics, or delivery, depending on the week of pregnancy and clinical status.
2. Uterine activity with progression of vaginal finding will result in course of antenatal steroids (if not already administered, or as a single course prior 34+0 if at least 7 days have passed after the previous course) and tocolysis

In patients with imminent preterm birth prior 32+0 week of pregnancy, foetal neuroprotection will be administered consisting of MgSO4 in an intravenous loading dose of 4 g (administered slowly over 20-30 min), followed by a 1 g per hour maintenance dose. This regimen should continue until birth but should be stopped after 24 h if undelivered.

Antibiotics - Group B Streptococcus (GBS) prophylaxis + macrolides, always at admission.

1. GBS prophylaxis + macrolides: Penicillin G (benzylpenicillin) 5mil IU IV initially and then 2-3 IU (dose adjusted to body weight) IV every 4h twice, then every 6h + Clarithromycin 500mg po every 12h for 7-10 days or till delivery.
2. Initial broad spectrum ABX: Ampicillin/sulbactam 3g IV every 6 hours + Gentamicin 5 mg/kg IV (<60 kg 240 mg, 61-80 kg 320 mg, >80 kg 400 mg) every 24h for 5-7 days according to the clinical state.

Comments:

Alternative ABX in patients with allergy to PCN/AMP: Vancomycin 1g IV every 12 h or Clindamycin 600-900g IV every 8h taking antibiotic sensitivity into account.

Before administering the third dose of gentamicin, its serum level should be determined (at a level >4 umol/l, the dose must be reduced).

List of short-term adverse maternal outcomes:

1. mortality
2. infection complication: sepsis, endometritis, wound infection, endometritis
3. postpartum haemorrhage
4. postpartum hysterectomy
5. admission to the maternal intensive care unit
6. unplanned operative procedure after delivery (dilation and curettage, laparoscopy, or laparotomy)
7. injury requiring repair
8. uterine rupture
9. haemorrhage of >1000 mL
10. transfusion
11. acute renal insufficiency
12. venous thromboembolism
13. pulmonary embolism
14. readmission to the hospital within 6 weeks

List of short-term neonatal outcomes:

1. mortality
2. gestational week at birth, birth weight and weight percentile
3. status of antenatal steroids (expired/complete/incomplete)
4. umbilical cord pH
5. IL-6 from the umbilical cord
6. Apgar score at 1 and 5 minutes
7. need of intubation of the neonate after birth
8. surfactant application
9. days on ventilator
10. the length of non-invasive respiratory support (postmenstrual week)
11. the need for home oxygen therapy
12. early pulmonary hypertension with iNO (Inhaled nitric oxide)
13. patent ductus arteriosus (PDA) over 14 days over 1.5 mm/ ligation/ left ventricular outflow (LVO) over 450 ml/kg/min in 14 days)
14. intraventricular haemorrhage (IVH) stage III-IV or periventricular leukomalacia (PVL) or other severe injury of brain visible on ultrasound
15. bronchopulmonary dysplasia (BPD) stage II and III (Jensen)
16. retinopathy of newborn (ROP) requiring invasive treatment
17. necrotizing enterocolitis (NEC) with need of surgical so