A Study to Assess Safety and Efficacy of Surgical Implant of RNDP-001 in Patients With Idiopathic Parkinson's Disease

A Phase 1b/2a Study Assessing the Safety and Efficacy of Intraputamenal Dopaminergic Stem Cell Transplants in Patients With Idiopathic Parkinson's Disease

This clinical trial is designed to test the safety and tolerability of the study intervention, RNDP-001, which will be implanted into the brain of study participants during a surgical procedure.

Inclusion Criteria:

• Diagnosis of idiopathic Parkinson's disease consistent with the Movement Disorders Society Clinical Criteria
• Age 45 to 75
• Medically stable to undergo a surgical procedure

Exclusion Criteria:

• Known Parkinson's disease gene mutation or variant
• Previous infusion therapy or surgery for Parkinson's disease
• History of allergic reaction or intolerance to an immunotherapeutic agent
• Contraindication to MRI
• Clinically significant medical conditions likely to interfere with the surgical procedure or study assessments