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Assess the uptake of rubidium-82 in parathyroid adenomas.
Parathyroid adenomas demonstrate uptake of rubidium-82 chloride and can be detected with PET imaging.
The investigators aim to describe the uptake pattern of rubidium-82 chloride in parathyroid adenomas as well as compare the uptake pattern of rubidium-82 chloride to that of 18F-fluorocholine in patients with parathyroid adenoma.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| PET/CT imaging with rubidium-82 | Other | PET imaging of the neck will be started immediately before infusion of 10 Megabecquerels per kilograms of rubidum-82 over 30 seconds. The acquisition will last 10 minutes. This will be followed by a non-contrast low-dose CT of the neck for localization and attenuation correction. |
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| Measure | Description | Time Frame |
|---|---|---|
| Uptake pattern of rubidium-82 in parathyroid adenomas | Rudibium-82 uptake will be assessed using Maximum Standardized Uptake Value (SUVmax) and target-to-background ratios (TBR). TBR is calculated by dividing a lesion SUVmax by the mean SUV (SUVmean) or the blood pool. Maximum Standardized Uptake Value (SUVmax) and target-to-background (TBR) will be presented as median with interquartile range as well as minimum and maximum values. | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Comparison between the uptakes of rubidium-82 and 18F-fluorocholine in patients with parathyroid adenomas | Radioactive tracer uptake will be compared between Rudibium-82 and 18F-Fluorocholine. Uptake will be assessed using Maximum Standardized Uptake Value (SUVmax) and target-to-background ratios (TBR). TBR is calculated by dividing a lesion SUVmax by the mean SUV (SUVmean) or the blood pool. Maximum Standardized Uptake Value (SUVmax) and target-to-background (TBR) will be presented as median with interquartile range as well as minimum and maximum values. |
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Inclusion Criteria:
Exclusion Criteria:
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20 participants with a diagnosis of primary parathyroid adenoma who have previously undergone 18F-fluorocholine imaging will be recruited.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Matthieu Pelletier-Galarneau, MD MSc | Contact | 514-376-3330 | 4418 | matthieu.pelletier-galarneau@icm-mhi.org |
| Pelletier-Galarneau | Contact |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Montreal Heart Institute | Montreal | Quebec | H1T 1C8 | Canada |
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| ID | Term |
|---|---|
| D010282 | Parathyroid Neoplasms |
| D049950 | Hyperparathyroidism, Primary |
| ID | Term |
|---|---|
| D004701 | Endocrine Gland Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D006258 | Head and Neck Neoplasms |
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| ID | Term |
|---|---|
| C000615479 | Rubidium-82 |
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| 3 months |
| Montreal Jewish General Hospital | Montreal | Quebec | H3T 1E2 | Canada |
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| D004700 |
| Endocrine System Diseases |
| D010279 | Parathyroid Diseases |
| D006961 | Hyperparathyroidism |