Generation of Cell Banks and Biomarker Isolation From Patients With Amyotrophic Lateral Sclerosis (ALS) (HCD-SLA)

Generation of Skin Fibroblast Banks, Urine-derived Cells and Biomarker Isolation From Patients With Amyotrophic Lateral Sclerosis (Als)

The aim of this research is to establish different cell banks from patients with amyotrophic lateral sclerosis (ALS).

The objective of this research is to:

• Create banks of skin fibroblasts from skin biopsy samples
• Create banks of urine-derived cells (UDCs) from urine samples
• Build a collection of blood samples to enable isolation of biomarkers.

Inclusion Criteria:

• Subjects over 18 years old;
• Subjects who have given their consent and signed an informed, free and express consent form;
• Subjects with diagnosed ALS;
• Subjects affiliated to or benefiting from a social security scheme.

Exclusion Criteria:

• Subjects with contraindications to the collection of biological samples (blood, skin, urine).
• Subjects undergoing treatment likely to affect hemostasis (anticoagulants, platelet anti-aggregants, etc.) in the month prior to inclusion and during the study;
• Subjects with hereditary or acquired haemostasis disorders;
• Subjects who have undergone physical treatment (radiotherapy, etc.) on the area to be biopsied in the last 6 months;
• Lidocaine-intolerant subjects;
• Subjects who have reached the age of majority and are subject to a protective measure or are unable to express their consent.