The aim of this research is to establish different cell banks from patients with amyotrophic lateral sclerosis (ALS).

The objective of this research is to:

• Create banks of skin fibroblasts from skin biopsy samples
• Create banks of urine-derived cells (UDCs) from urine samples
• Build a collection of blood samples to enable isolation of biomarkers.

Inclusion Criteria:

• Subjects over 18 years old;
• Subjects who have given their consent and signed an informed, free and express consent form;
• Subjects with diagnosed ALS;
• Subjects affiliated to or benefiting from a social security scheme.

Exclusion Criteria:

• Subjects with contraindications to the collection of biological samples (blood, skin, urine).
• Subjects undergoing treatment likely to affect hemostasis (anticoagulants, platelet anti-aggregants, etc.) in the month prior to inclusion and during the study;
• Subjects with hereditary or acquired haemostasis disorders;
• Subjects who have undergone physical treatment (radiotherapy, etc.) on the area to be biopsied in the last 6 months;
• Lidocaine-intolerant subjects;
• Subjects who have reached the age of majority and are subject to a protective measure or are unable to express their consent.

ALS patients who are part of a cohort from the ALS Center of Toulouse University Hospital and are treated at that hospital.