Inflammatory bowel diseases (IBD) are progressively increasing their prevalence worldwide. Up to half of patients may also have extraintestinal manifestation and cardiovascular diseases (CVDs) is one of the most relevant, being the second cause of death in these patients. The classical cardiovascular (CV) risk scores do not adquately capture the CV risk in IBD.

We are planning a prospective observational study to evaluate patients with IBD and a gender/age-matched cohort with the aims to investigate in 2-years follow-up

• Occurrence of major cardiovascular events (MACEs) in both cohorts;
• Predictive factors of risk for MACEs in IBD compared to controls;
• Multi-omics evaluations with the support of artificial intelligence of biomarkers associated with occurrence of MACEs in IBD

Inclusion Criteria:

Patients with confrimed diagnosis of Crohn's disease and Ulcerative colitis-

Exclusion Criteria:

No willing to sign the informe content and have 2 years of follow-up

IBD patients willing to remain in follow-up for 2 years

Characteristics of Study and control cohorts

At the end of Follow-up (End of 2028). It will be available for 5 years

Any researcher, provided that will have an approved scientific plan to gather clinical info of the study (IBD) and control cohorts