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| Name | Class |
|---|---|
| San Raffaele University Hospital, Italy | OTHER |
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This study aims to better understand Obsessive-Compulsive Disorder (OCD) by examining the types and patterns of OCD symptom presentation. The investigators seek to determine how these symptoms impact overall daily functioning.
The study will also explore factors contributing to loss of insight in individuals with OCD, focusing on the potential roles of trauma, personality traits, and disorder severity. This may assist in identifying subgroups of patients who respond more favorably to treatment.
Additionally, the study will investigate how individuals with OCD and schizophrenia spectrum symptoms respond to combined sensory stimuli (e.g., auditory and tactile). The goal is to determine whether these responses are associated with specific brain processing patterns, trauma history, or characteristics of compulsive behavior. Insights from this research may help clarify why certain individuals develop repetitive behaviors such as checking and rituals.
Participants will be adults aged 18 to 65 diagnosed with OCD or schizophrenia spectrum disorders. Recruitment will occur through psychiatric clinics in Parma. Participation requires signed informed consent.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Psychopathological assessment and non-invasive multisensory stimulation | Other | This intervention consists of a non-invasive, cross-sectional assessment involving standardized psychopathological interviews and multisensory stimulation tasks (auditory, tactile, and combined). It is designed to explore formal and content-related features of obsessive-compulsive symptoms, insight levels, and trauma-related correlates in patients with OCD and schizophrenia spectrum disorders. No pharmacological treatment or experimental therapy is administered as part of this study. |
| Measure | Description | Time Frame |
|---|---|---|
| Yellbrown (Y-BOCS) Score | Assessment of obsessive-compulsive symptom severity using the Yellow-Brown Obsessive-Compulsive Scale (Y-BOCS). The total score ranges from 0 to 40, with higher scores indicating more severe symptoms. This scale is a clinician-administered questionnaire evaluating obsessions and compulsions | Baseline (single evaluation session) |
| Measure | Description | Time Frame |
|---|---|---|
| Childhood Trauma Questionnaire-Short Form (CTQ-SF) Total Score | Measurement of childhood trauma exposure using the Childhood Trauma Questionnaire-Short Form (CTQ-SF), a self-report questionnaire with scores ranging from 25 to 125. Higher scores indicate greater levels of reported childhood trauma | Baseline (single evaluation session) |
| Measure | Description | Time Frame |
|---|---|---|
| Structural Analysis of Rituals | Behavioral analysis of ritual videos conducted with ethnographic software, which breaks down rituals into elementary behavioral units classified into three categories: functional, non-functional, and displaced. The measure quantifies the frequency of each behavioral unit category to assess the complexity and structure of rituals. Frequency counts of behavioral units per category (functional, non-functional, displaced). Baseline and follow-up video recordings. |
Inclusion Criteria:
Exclusion Criteria:
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The patients are affiliated with the facilities of the Integrated Department of Mental Health and Pathological Addictions (DAI-SMDP) of the Parma Local Health Authority (AUSL Parma)
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Parma | Parma | Emilia-Romagna | 43121 | Italy | ||
| Università degli Studi di Parma - Dipartimento di Medicina e Chirurgia |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 3789205 | Background | Insel TR, Akiskal HS. Obsessive-compulsive disorder with psychotic features: a phenomenologic analysis. Am J Psychiatry. 1986 Dec;143(12):1527-33. doi: 10.1176/ajp.143.12.1527. | |
| 27567192 | Background | Innamorati M, Erbuto D, Venturini P, Fagioli F, Ricci F, Lester D, Amore M, Girardi P, Pompili M. Factorial validity of the Childhood Trauma Questionnaire in Italian psychiatric patients. Psychiatry Res. 2016 Nov 30;245:297-302. doi: 10.1016/j.psychres.2016.08.044. Epub 2016 Aug 16. |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot | Yes | No | No | Study Protocol | May 17, 2025 | Aug 6, 2025 |
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| Simultaneity Judgement Task (SJ) Performance |
Assessment of audio-tactile simultaneity perception using paired auditory and tactile stimuli presented with varying temporal delays. Participants are asked to judge whether the stimuli occur simultaneously. The task includes multiple trials with systematically varied stimulus onset asynchronies. Performance is defined as the proportion of correct simultaneity judgments, reflecting multisensory temporal integration abilities |
| Approximately 15 minutes during the pre-training session |
| Simultaneity Judgement Training (SJT) Performance | Evaluation of training-induced improvements in multisensory temporal integration through a task where participants receive real-time feedback on their simultaneity judgments. A staircase procedure adjusts the delay between stimuli based on participant responses. Performance is measured as improvement in simultaneity judgment accuracy and reduced temporal thresholds from pre- to post-training sessions | Approximately 30-45 minutes during the training session |
| Baseline (single evaluation session) |
| Parma |
| 43124 |
| Italy |
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| Prot_003.pdf |
| ICF | No | No | Yes | Informed Consent Form: Informative Document | May 17, 2025 | Jul 12, 2025 | ICF_001.pdf |
| ICF | No | No | Yes | Informed Consent Form: Informed Consent Form | Jan 28, 2023 | Jul 12, 2025 | ICF_002.pdf |
| ID | Term |
|---|---|
| D009771 | Obsessive-Compulsive Disorder |
| D012559 | Schizophrenia |
| ID | Term |
|---|---|
| D001008 | Anxiety Disorders |
| D001523 | Mental Disorders |
| D019967 | Schizophrenia Spectrum and Other Psychotic Disorders |
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