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The goal of this observational study is to test an artificial intelligence (AI) tool that can help screen for mental health risks . The main questions it aims to answer are:
Can an AI model that analyzes a person's voice, facial expressions, and language accurately identify students who may be at high risk for mental health conditions, such as depression or OCD?
How accurate is the AI model when compared to results from standard mental health questionnaires?
Participants will be asked to:
Complete a standard mental health questionnaire.
Provide consent for their data to be used in the research.
Participate in a recorded session to collect video and audio data for the AI model to analyze.
This large-scale, multi-center observational study aims to develop and validate a novel artificial intelligence (AI) model for the early and objective screening of mental health risks, such as depression and OCD, in university students. The model will be trained and internally validated on multimodal data (including vocal, facial, and linguistic features) from a large student cohort. A subsequent neuroscience sub-study will explore the neurobiological correlates of the AI-identified risk levels using electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) to establish biological validity. The primary outcome is to assess the final model's diagnostic accuracy, quantified by its sensitivity, specificity, and AUC, with the ultimate goal of providing a scalable and efficient early warning tool to facilitate timely clinical intervention for university populations.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Healthy Control | without mental healthy problem |
| |
| Mental Diseases | with mental problem, such as depression, OCD |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| AI model | Diagnostic Test | An AI model provides an objective and rapid assessment of potential mental health risks in students by holistically analyzing their facial expressions, vocal characteristics, and linguistic content from data. |
| Measure | Description | Time Frame |
|---|---|---|
| Sensitivity | through study completion, an average of 1 year | |
| AUROC | Area Under the Receiver Operating Characteristic Curve | through study completion, an average of 1 year |
| Specificity of the AI Model for Mental Health Screening | The ability of the AI model to correctly identify students without significant psychological distress. It will be calculated as the percentage of participants correctly classified as 'low-risk' by the AI model compared to a 'gold standard' classification | through study completion, an average of 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| Positive and Negative Predictive Values | through study completion, an average of 1 year | |
| Correlation Between AI-Identified Risk Scores and Neurobiological Markers | To assess the biological validity of the AI model, the model's output will be correlated with specific neurobiological markers obtained from a sub-study. The correlation will be assessed using a Pearson correlation coefficient. |
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Inclusion Criteria:
Exclusion Criteria:
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The study population comprises a large cohort of students recruited from multiple universities. Participants will be included in the main phase for AI model development. Additionally, a sub-group of students will be selected based on their mental health risk levels (e.g., for depression or OCD) to participate in a subsequent neuroscience sub-study.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Peking Union Medical College | Beijing | Beijing Municipality | China |
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| ID | Term |
|---|---|
| D001523 | Mental Disorders |
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| through study completion, an average of 1 year |