Melatonin Effects on the Left Ventricular Function in Neonates With Persistent Pulmonary Hypertension

Melatonin Effects on the Left Ventricular Function in Neonates With Persistent Pulmonary Hypertension

This study aimed to evaluate the effect of melatonin on the left ventricular function in neonates with persistent pulmonary hypertension

Persistent pulmonary hypertension of the newborn (PPHN) is a potentially deadly disorder in which the circulation of the fetus is unable to adjust to the extrauterine environment. Persistently high pulmonary pressures may cause right-to-left shunting, hypoxia, and right ventricular failure.

Melatonin, a neurohormone produced by the pineal gland, offers an exceptional defense against reactive oxygen species (ROS). Infants are unable to synthesize melatonin during their first few weeks of life, which may exacerbate oxidative stress in hypoxic conditions. Additionally, Melatonin's antioxidative capabilities have been shown in neonatal pulmonary and respiratory disorders.

Inclusion Criteria:

• Neonates of ≥ 36 weeks of gestational age.
• Both sexes.
• Admitted with persistent pulmonary hypertension.

Exclusion Criteria:

• Preterm infants < 36 weeks of gestation.
• Infants with congenital heart diseases.
• Infants with dysrhythmia.
• Chromosomal abnormalities.
• Severe pathological jaundice.
• Metabolic or endocrinal disorders.
• Major congenital malformations.