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The purpose of the study is to determine the effects of HA, PRP and the combination of HA and PRP in reducing pain and improving functional disability in patients with knee osteoarthritis.
To determine the effects of combination of platelet rich plasma (PRP) and hyaluronic acid and the PRP or HA alone in reducing pain and increasing range of motion among individuals with knee osteoarthritis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group A | Experimental | Hyaluronic acid |
|
| Group B | Active Comparator | platelet rich plasma |
|
| Group C | Other | Hyaluronic acid and platelet rich plasma |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Hyaluronic Acid (HA) | Drug | Hyaluronic Acid |
| |
| Platelet Rich Plasma |
| Measure | Description | Time Frame |
|---|---|---|
| visual analogue scale | It is a straight line, 100 millimeters long line, one end of the line means "not at all" or "none" and the other end means "the worst possible" or "extremely". | Recorded before the treatment and repeated within 3 and 6 months after the treatment. |
| Measure | Description | Time Frame |
|---|---|---|
| Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) | It s a questionnaire used to assess pain, stiffness, and physical function in individuals with osteoarthritis, particularly of the knee. It is a self-administered, multidimensional tool that evaluates these three dimensions through a series of questions, typically on a Likert scale. | Recorded before the treatment and repeated within 3 and 6 months after the treatment. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Basit Ansari, PhD | University of Karachi | Study Chair |
| Ranjeet Kumar, MBBS, FCPS | University of Karachi | Principal Investigator |
| Aftab Ahmed Mirza Baig, PhD | IQRA University | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| South City Hospital | Karachi | Sindh | 75600 | Pakistan |
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| ID | Term |
|---|---|
| D010003 | Osteoarthritis |
| D010146 | Pain |
| ID | Term |
|---|---|
| D001168 | Arthritis |
| D007592 | Joint Diseases |
| D009140 | Musculoskeletal Diseases |
| D012216 | Rheumatic Diseases |
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| ID | Term |
|---|---|
| D006820 | Hyaluronic Acid |
| ID | Term |
|---|---|
| D006025 | Glycosaminoglycans |
| D011134 | Polysaccharides |
| D002241 | Carbohydrates |
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Participants were randomly divided into three groups. Twenty cases (Group A) were injected with HA, 20 (Group B) had PRP, and the remaining 20 (Group C) received a combination of HA and PRP
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Single blinded study, only the assessor was kept blinded
| Drug |
Platelet rich plasma |
|
| Hyaluronic Acid (HA) and Platelet rich plasma | Drug | Hyaluronic Acid and Platelet rich plasma |
|
| D009461 |
| Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |