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Lower segment C section is one of the most commonly performed surgeries worldwide. It is performed in spinal anesthesia. During Spinal Anesthesia a local anesthetic drug is administered in a space surrounding spinal cord and it blocks nerves originating from spinal cord providing both anesthesia and analgesia. This technique avoids harmful exposure of drugs to the baby inside the womb of mother. However this technique provides anesthesia and analgesia of limited duration which can be prolonged by addition of drugs to patient management regimen. One such drug is Dexamethasone which is a steroid commonly administered in the peri-operative period.
To prolong the duration of Sub-Arachnoid block number of drugs which are known as adjuvants can be used. One of the commonly used adjuvant is Dexamethasone a steroid given by intravenous route having anti-emetic and anti-inflammatory effect. This drug also prolongs the duration of Sub-Arachnoid block which can be helpful in case of lengthy surgical procedure and also extends the duration of analgesia in the post operative period.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group Dexamethasone | Experimental |
| |
| Group Control | Placebo Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Dexamethasone | Drug | Immediately after sub-arachnoid block 8mg of Dexamethasone will be administered intravenously |
|
| Measure | Description | Time Frame |
|---|---|---|
| Time for block to regress by two dermatomes in post operative period | This will be the time in minutes from end of C section in post operative period for the block to regress by two dermatomes |
| Measure | Description | Time Frame |
|---|---|---|
| Time to rescue analgesia | This will be the time in minutes from the end of Cesarean section in the post operative period to first rescue analgesia. |
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Huda Tariq, MBBS | Contact | +92-321-8829413 | Huda8829@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Abeera Zareen, MBBS,FCPS | Rawalpindi Medical College | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Benazir Bhutto Hospital Rawalpindi | Recruiting | Rawalpindi | Punjab Province | 46000 | Pakistan |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 37736711 | Result | Abdel-Wahab AH, Abd Alla ES, Abd El-Azeem T. Effect of intravenous dexamethasone on the duration of hyperbaric bupivacaine spinal anesthesia in lower abdominal surgery, Randomized controlled trial. BMC Anesthesiol. 2023 Sep 22;23(1):323. doi: 10.1186/s12871-023-02282-y. |
| Label | URL |
|---|---|
| Related Info | View source |
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| ID | Term |
|---|---|
| D003907 | Dexamethasone |
| ID | Term |
|---|---|
| D011246 | Pregnadienetriols |
| D011245 | Pregnadienes |
| D011278 | Pregnanes |
| D013256 | Steroids |
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| Placebo | Drug | 2ml of Normal saline will be given intravenously immediately after administration of spinal anesthesia |
|
| D000072473 |
| Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |
| D013259 | Steroids, Fluorinated |