The participants will receive myofascial release, for 15 minutes, three times per week for 6 weeks (total of 18 sessions), in addition to night splint and home advice.

The participants will receive acupressure on pericardium 6 acupoint (PC-6 point) for 3 minutes, three times per week for 6 weeks (total of 18 sessions), in addition to night splint and home advice.

All participants will be treated conservatively by wrist splint in a neutral position.

The visual analogue scale (VAS) will be used to assess pain intensity before and after intervention. The VAS is usually presented as a 10-cm horizontal line on which the patient's pain intensity is represented by a point between the extremes of "no pain at all" and "worst pain imaginable."

Electromyography device (Tru Trace EMG, 2ch Head box device, manufactured by deymed Diagnostic Pvt., Ltd., Czech Republ) will be used to assess sensory conduction velocity of median nerve before and after the treatment. A pair of ring electrodes will be placed on the index finger for recording, and the sensory nerve will be stimulated antidromically. The stimulating electrodes will be placed at the wrist proximal to carpal tunnel for the distal segment stimulation and at the elbow medial to biceps tendon for the proximal segment stimulation.

Conduction velocity is the speed at which the electrical signal travels along the nerve. A reduced velocity can also indicate nerve damage. Its normal range is from 44-60 ms.

Electromyography device (Tru Trace EMG, 2ch Head box device, manufactured by deymed Diagnostic Pvt., Ltd., Czech Republ) will be used to assess sensory distal latency of median nerve before and after the treatment. A pair of ring electrodes will be placed on the index finger for recording, and the sensory nerve will be stimulated antidromically. The stimulating electrodes will be placed at the wrist proximal to carpal tunnel for the distal segment stimulation and at the elbow medial to biceps tendon for the proximal segment stimulation. The distal motor latency is measured from the onset of the stimulating artifact to the onset of the compound muscle action potential. Its normal range is from 2.5-3.5 ms.

The amplitude of the median nerve (specifically, the sensory nerve action potential, or SNAP) will be measured by electromyography (Tru Trace EMG, 2ch Head box device, manufactured by deymed Diagnostic Pvt., Ltd., Czech Republ) during nerve conduction study before and after treatment. It is measured in microvolts (µV) and reflects the number of nerve fibers conducting the electrical signal. During a nerve conduction study, a small electrical stimulus is applied to the median nerve, and the resulting electrical activity is recorded. The amplitude is then measured as the height of the waveform generated by this activity. Its normal value should be at least 6 microvolt (6 µV).

Boston Carpal Tunnel Questionnaire will be used before and after intervention. It comprises two scales, a symptom severity scale (SSS) and a functional status scale (FSS). The SSS evaluates symptoms with regard to severity, frequency, and time. The FSS indicates how the syndrome affects daily life. SSS involves 11 questions, addressing: pain intensity during day time and night time, time of pain during the day, numbness, weakness, tingling sensation at night, frequency of night tingling sensation, and skill. Each question offers 5 answers, from 0 points (no symptoms) to 4 points (most severe symptoms). Questions concerning FSS refer to daily activities that will be performed by most individuals and are commonly affected by CTS. The patients rate their ability to perform each activity on a scale that ranged from 1 point (no difficulty with the activity) to 5 points (cannot perform the activity at all).The overall score for the FSS is the mean of the ratings on the daily activities.