Not provided
Not provided
Not provided
| ID | Type | Description | Link |
|---|---|---|---|
| 2023-A01037-38 | Other Identifier | ID RCB |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Chronic inflammatory rheumatisms (CIR) are a source of motor disability and various comorbidities, particularly cardiovascular and metabolic. They also significantly impact patients' quality of life, including sleep disturbances. Among CIRs, psoriatic arthritis is a chronic inflammatory arthropathy associated with psoriasis, typically seronegative for rheumatoid factor. This heterogeneous disease affects peripheral and/or axial joints and can include extra-articular manifestations such as uveitis and chronic inflammatory bowel diseases. Its prevalence is estimated between 0.3% and 1% in the general population.
SAPHO syndrome, similar to psoriatic arthritis, is characterized by specific bone involvement with a hypertrophic tendency, often affecting the axial skeleton and the anterior thoracic wall. Pain and inflammation are closely linked to sleep quality, creating a vicious cycle where pain disrupts sleep and poor sleep amplifies pain perception. Analgesic treatments, such as opioids, can also cause nocturnal respiratory pathologies, further disrupting sleep.
Inflammatory processes are regulated by sleep, influencing plasma concentrations of CRP, IL6, and TNF production. Patients with psoriatic arthritis or SAPHO syndrome share common risk factors with Obstructive Sleep Apnea Syndrome (OSAS), such as obesity, hypertension, and metabolic syndrome.
Sleep disorders are common in the general population and likely underdiagnosed in these patients. Several studies suggest a link between sleep disorders and these rheumatic conditions, affecting quality of life and exacerbating symptoms. Questionnaires like the Epworth and Pichot scales provide a more precise evaluation of these symptoms. However, objective sleep exploration through polysomnography has never been conducted in these patients.
In summary, CIRs, particularly psoriatic arthritis and SAPHO syndrome, significantly impact patients' quality of life and sleep, necessitating appropriate evaluation and management of associated sleep disorders.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| No sleep disorder | |||
| sleep apnea | |||
| other sleep disorder |
Not provided
| Measure | Description | Time Frame |
|---|---|---|
| Type of sleep disorders | sleep disorders will be defined after polysomnography exam. | at 6months |
| Measure | Description | Time Frame |
|---|---|---|
| sleep structure | quantity of the different sleep stages as observed on the polysomnography exam | at 6 months |
| presence and severity of asthenia, | mesured by the PICHOT questionnar |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
patient diagnosed with psoriasis arthritis or SAPHO syndrome and presenting sleep disorder
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Juliette COURTIADE MAHLER | Contact | +33144127963 | jcourtiade@ghpsj.Fr |
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hôpital Paris Saint Joseph | Recruiting | Paris | France |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| at enrollement |
| evaluation of anxiety | mesured by HAD questionnaire | at enrollement |
| drowsiness evaluation | mesured with the Epworth Scale | at enrollement |
| Evaluation of Sleep Apnea | mesured with the STOP BANG questionnaire | at enrollement, at 6months and at 12 months |
| Sleep apnea severy | mesured by the Apnea/hypopnea index | at enrollemnt, 6months and 12 months after |
| Rheumatism disease activity | mesured with the DPASA score | at enrollement, after 6 months and after 12 months |
| CRP mesurement | expressed in mg/L | at enrollment, 6months and 12 months after |
| ID | Term |
|---|---|
| D020083 | Acquired Hyperostosis Syndrome |
| D012891 | Sleep Apnea Syndromes |
| ID | Term |
|---|---|
| D010009 | Osteochondrodysplasias |
| D001848 | Bone Diseases, Developmental |
| D001847 | Bone Diseases |
| D009140 | Musculoskeletal Diseases |
| D001049 | Apnea |
| D012120 | Respiration Disorders |
| D012140 | Respiratory Tract Diseases |
| D020919 | Sleep Disorders, Intrinsic |
| D020920 | Dyssomnias |
| D012893 | Sleep Wake Disorders |
| D009422 | Nervous System Diseases |
Not provided
Not provided