Dynamic Motor Cortical Responses to Subdural Electrical Stimulation.

Dynamic Motor Cortical Responses to Subdural Electrical Stimulation.

The purpose of this study is to better understand how subdural electrical stimulation of the brain affects motor cortical oscillations

Direct cortical stimulation (DCS) has shown the potential to improve symptoms in patients with Parkinson's disease, however its effects have not been consistent in randomized studies to date, limiting widespread adoption of this technology. A critical gap in our knowledge is a detailed understanding of how DCS affects motor areas in the brain. Investigators propose using subdural DCS (sDCS) while simultaneously recording directly from motor cortex using subdural electrocorticography (sECoG) in patients undergoing deep brain stimulation surgery. Investigators expect this novel approach to broaden our understanding of sDCS application and possibly lead to therapeutic advances in this population.

Inclusion Criteria:

• Patients diagnosed with PD and consented and scheduled for DBS surgery with the PI
• Age 18-80

Exclusion Criteria:

• Patients unable to actively participate in the consent process physically and/or cognitively
• Previous adverse reaction to Keppra (levetiracetam)
• Prior intracranial surgery with the exception of deep brain stimulation surgery
• Prior brain radiotherapy
• Prior history of intracranial tumor, intracranial infection or cerebrovascular malformation
• Prior history of seizures